Jundishapur Scientific Medical Journal
Year:2018 | Volume:17 | Issue:1 |Papers Count:11

Background and Objectives: It seems that exercise training and shortly after ingestion of green tea extract (GTE) fat oxidation increases The purpose of this study was to investigate the combined effect of short term GTE and a single bout of cycle ergometer upon plasma glycerol, fatty acids and insulin levels.Subjects and Methods: Sixteen healthy volunteer men were recruited and divided into two equal groups; experimental group (n=8) and placebo group (n=8), respectively. They consumed three GTE or placebo capsules one day before and one capsule 90 min before a cycling protocol. Blood samples were collected from all participants before and after the protocol.Results: Plasma glycerol, free fatty acids and insulin levels of experimental group were significantly higher after GTE consumption after post-exercise compared to placebo (P<0.05).While no significant differences were objesrved in the placebo group.Conclusion: Therefore, it seems that acute GTE ingestion could increase fat oxidation after post exercise conditions.

Background and Objectives: Cryotherapy is often used as an immediate treatment method to relieve acute pain of soft tissue injuries. The current study aimed to investigate the direct effect of quadriceps muscles cooling with ice spray on plantar pressure variables during stance phase of running in male soccer players.Subjects and Methods: Seventeen healthy male soccer players with mean age of 23.7±3.3 years were recruited to participate in this study. Data were collected using a foot scan pressure-sensitive floor mat (RsScan International Footscan®) which was flush mounted in the 10th m of a 15 m-long walkway. The software divided the foot into 10 separate anatomical regions. Participants were instructed to run before and after cryotherapy, which was established following a warm-up period from three trials along a 15 m walkway. After pretest, the subjects were asked to lie down in a supine position, and ice spray was used for cryotherapy.Results: Significant increases in peak plantar pressure variables of toe (P=0.003) and first metatarsal areas (P<0.043) of foot were observed after cryotherapy during stance phase of running.Conclusion: The results suggest that cryotherapy during sporting events such as running may place the individuals in a vulnerable injurious position.

Background and Objectives: Sleep is a reversible state in which the capacity for reaction and interaction with the environment is limited and consciousness is lost. 5HT3 receptors are mainly expressed in hippocampus CA1 regions, plays a vital role in sleep regulation and memory consolidation. The present study aims to investigate the effects of activation and inactivation of serotonin 5HT3 receptor by use of 5HT3 agonist and antagonist (MCHL and Y25130) respectively on acquired memory impairment induced by total sleep deprivation and REM sleep deprivation in rat.Subjects and Methods: Male Wistar rats were randomly assigned to five groups including eight rats: 1-Two groups receiving effective doses of 5HT3 receptor antagonist (MCHL) and agonist (Y25130); 2- TSD control group 3-With TSD sleep deprivation 4-RSD control groups 5- with RSD sleep deprivation. Water box apparatus was used to induce total sleep deprivation, multi-platform apparatus was applied to induce RSD. Passive avoidance memory test was used to evaluate memory consolidation.Results: Doses of 0.01 and 0.001 mg MCHL and 0.1 mg Y25130 significantly reduced the acquired memory (P<0.01). While MCHL at 0.1 and Y25130 at doses of 0.01 and 0.1 significantly increased motor activities (P<0.01). However, both drugs did not significantly affect the pain at all tested doses. TSD and RSD- induced amnesia was improved significantly (P<0.01) by Y25130 with sub- threshold dose. While both drugs had no significant effect on motor activity in TSD and RSD conditions (P>0.05). But, MCHL under RSD conditions and Y25130 under TSD conditions significantly (P<0.01) increased analgesia.Conclusion: It seems that CA1 5HT3 receptor plays a critical role in cognitive and non-cognitive behaviors included by TSD and RSD.

Background and Objective: Low levels of 25-Hydroxyvitamin D are associated with obesity and anthropometric indices. Therefore, the aim of this study was to determine the effect of aerobic interval exercise training on serum levels of 25-OH Vitamin D and anthropometric indices in obesity and overweight women.Subjects and Methods: In this research semi-experimental study, 20 obese and overweight women aged between 30 to 50 years. and mean BMI of 31.71±2.59 Kg/m2 referring to the Ahvaz Jundishapur University Clinic were selected purposefully. And randomly They were divided into intervention and control groups.The training program consisted of 30-45 minutes of aerobic interval exercise with intensity of 50-70% and 40-4540% of maximum heart rate, respectively, 2 minutes of exercise and 2 minutes of active rest, 3 sessions/ week for 8 weeks. Anthropometric and serum level of 25-hydroxyvitamin D were measured before and after intervention in both groups. Data analysis was performed using independent and dependent t test at a significant level (P£0.05).Results: After eight weeks of of aerobic interval exercise training, a significant increase was observed in levels serum 25-hydroxyvitamin D (P=0.002). Which was associated with a significant decrease in body fat percentage, waist to hip ratio and body mass index in overweight and obese women (P<0.05).Conclusion: Eight weeks of aerobic interval exercise training can improve body composition and increase serum 25-hydroxyvitamin D levels in overweight and obesity women.

Background and Objective: Pilates training is a training method that creates positive changes in body composition, flexibility and muscle function. The present study was carried out with the aim of evaluating the effect of pilates training on body composition, lipid profile and some indicators of physical fitness in obese sedentary women.Subjects and Methods: In this study, 24 sedentary obese women (mean age 38.4±8.61 years and BMI 35.6±2.95 Kg/m2) participated voluntarily and were randomly divided into pilates group (n=15) and control group (n=9). Pilates group performed training program with 14-16 RPE for 8 weeks, 3 times/week. Of all subjects was obtain, before and after training program, features of body composition, some physical fitness indices and lipid profile were taken from all subjects. Data were analyzed using paired-sample T-test and ANOVA.Results: After 8 weeks of pilates training, there was no significant changes in body weight, body mass index, body fat percentage, lean body mass and lipid profile (TC, TG, LDL, VLDL, HDL) (P³0.05), While a significant increase was observed in flexibility of back and front trunck muscles, excellent hand power, power foot and modified swimming.Conclusion: According to these results, it seems that eight weeks of pilates training, despite the improvement of physical fitness, is not effective on body composition and lipid profile.

Background and Objective: Type 2 diabetes mellitus is a complex heterogeneous group of metabolic disorders characterized by increased levels of blood glucose due to impairment in insulin action and/or insulin secretion. The SLC30A8 gene is considered as one of the most important candidate genes of type 2 diabetes. The objective of this study was to evaluate the distributuion of this gene among our patients in Mazandaran, Iran.Subjects and Methods: In this case-control study, 135 patients and 76 healthy subjects were recruited. Five ml of peripheral blood of diabetics and healthy subjects (controls) was collected in EDTA-containing tubes. Genomic DNA was extracted using salting-out method and genotype and allele frequencies of the rs13266634 polymorphism were investigated using PCR-RFLP method.Results: Genotype and allele frequencies of the rs13266634 polymorphism differed significantly between type 2 diabetic patients and non-diabetic subjects (P=0.0003 and P=0.0664, respectively). The frequency of C allele was 89% in type 2 diabetes group and 67% in non-diabetic subjects, and this allele was significantly associated with type 2 diabetes risk (OR=10.0, 95% CI 1.9124-591.3058, 2.924- 924.239).Conclusion: Our results confirm the association between the rs13266634 polymorphism of the SLC30A8 gene and the increased risk of type 2 diabetes among the West Mazandaran population.

Background and Objectives: Varicocele is the abnormal dilation and tortuosity of venous plexus (venous) above the testicles. The pattern of abnormal heat distribution in the scrotum can be diagnosed using thermal imaging. Thermal imaging is a distant, non-contact, and non-invasive method.Subjects and Methods: This study is descriptive-analytical one. Using a non-contact infrared camera (SDS Hotfind L) and taking images of 50 patients with varicocele.Capabilities of thermography were studied and evaluated.The variables studied in this research include age, marital status, smoking, and temperature of (Scrotum, Pampiniform venous plexus).Results: In two cases, with the help of heat distribution, varicocele was detected using a thermal camera; one was thermal asymmetry and increased temperature in venous plexus pampiniform and the other was differences in features obtained from wavelet transform in healthy and varicloceled cases. If the index was only the diagnosis of varicocele, according to Gold standard of Doppler ultrasound, the sensitivity of thermography was 70 % with 88.23 %specificity.Conclusion: The results of this study indicate that the thermography for the diagnosing varicocele is more suitable way as a complementary method. Additionally, testicular thermography can be used for early and rapid screening with many samples sizes in places such as barracks and areas where the use of ultrasound devices cannot be used.

Background and Objective: Chronic blood transfusions are effective in preventing both initial and recurrent strokes in patients with sickle cell disease (SCD). Individuals with high iron burden are at significant risk for end organ damage and death due to cardiac and liver complications. For this reason patients receiving chronic blood transfusions are placed on the iron chelator desferrioxamine.Monitoring body iron content is critical for clinical management of patients with iron overload. The objective of this study was to evaluate if there is a correlation between serum ferritin level with the liver and heart MRI results.Subjects and Methods: This study was a cross-sectional study based on the demographic and the patient’s laboratory and imaging results including age, sex, serum ferritin, hemoglobin, heart and liver MRI T2*. Analysis after determining the sample size required to estimate the correlation between ferritin or hemoglobin using resampling method. To detect the correlation between serum ferritin and MRIT2* heart or liver in sickle cell disease the Pearson and Spearman correlation coefficient was used.Results: Although, there was no significant correlation between hemoglobin and heart and liver MRI T2*, but there was significantly inverse correlation between serum ferritin and heart and liver MRI T2* in sickle cell anemia patients.Conclusion: To better evaluate the iron overload of liver and heart in sickle cell anemia patients, measurement of serum ferritin or MRI T2* is suggested and can be used instead of each other in some circumstances.

Background and Objective: Due to the low side effects of active ingredients of medicinal plants, they are considered appropriate alternatives to synthetic drugs.Malva periflora has antiinflammation effects in folk and herbal medicine. In this study the anti-nociceptive and anti-inflammatory effects of Malva parviflora were investigated.Subjects and Methods: In this study seventy two Wister male rats were used: negative control group that received no treatment, sham group received normal saline (1ml), Test groups received respectively 100, 200, 400, 600 or 800 mg/Kg extract for 10 days by gavages. Positive control group received 600 mg/Kg extract with 300 mg/Kg Aspirin intraperitoneally; Group received 600 mg/Kg extract and naloxone (10 mg/Kg) intraperitoneally. Pain was tested by formalin test by subcutaneous administration of 50 ml formalin 2.5% in hindpow plantar.Results: Malva extract had a dose-dependent anti-nociceptive effect on both acute and chronic pains induced by the formalin injection (P<0.05). In the acute phase Malva lost its analogesic effect due to the inhibitation of opioid receptor by naloxone. But in the inflammatory phase, this effect was weaker in comparison with aspirin. On the other hand, effective dose (600 mg/Kg) of extract with naloxone decreased significantly as compared to effective dose of extract alone.Conclusion: Malva parviflora extract has flavonoid and antiinflammatory compounds. Yet prostaglandins release could probably be decreased by inhibiting cyclooxygenase activity.So it reduces pain in chronic phase thanks to its anti-inflammatory properties.

Background and Objectives: Seizure is one of the most common symptoms of epilepsy caused by abnormal electrical activity of neurons; Because of the side effects of chemical drugs the use of herbal medicines can be a good alternative to seizure control. In this study the effectiveness of Ferulagoangulata (Schlecht, Boisss) hydroalcoholic extract was investigated in pentylenetetrazole (PTZ) -induced seizure in male mice.Subjects and Methods: In this experimental study, 48 male mice weighing 25-30g were divided into 6 groups': saline; positive control group (received diazepam as standard an anticonvulsant drug at 1 mg/Kg) and 4 experimental groups (100, 200, 400, 800 mg/Kg of extract) respectively. All the animal groups received intraperitoneallypentylenetrazole (85 mg/Kg), 30 minutes after appropriate treatment protocol.Results: Injection of Ferulagoangulata hydroalcoholic extract delayed the onset of seizure at 400 dose (P<0.001), and reduced the duration of clonic seizure, which had the highest effect in doses of 200 and 400 mg/kg P<0.01 and P<0.001 respectively. Also, administration of hydroalcoholic extract of Ferulagoangulatacaused a decrease in the duration of tonic-clonic and decreased the total duration of seizure in animals. Diazepam improved seizures in all cases. The dosage of 200 and 400 mg of extract was similar to diazepam.Conclusion: In general, intraperitoneal injection of Ferulagohydroalcoholic extract causes delay in attacks in various phases of seizureand it seems the future studies will be necessary to separate its ingredients and understand its mechanism of action.