THE EFFECT OF INTRAPERITONEAL INJECTION OF FERULAE ANGULATAHYDROALCOHOLIC EXTRACT ON PENTYLENETETRAZOLE-INDUCED EPILEPSY IN MALE MICE

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ETEMADI KERMANI SHOHREH; RAFIEE RAD MARYAM

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Journal: Jundishapur Scientific Medical Journal Year:2018 | Volume:17 | Issue:1 Page(s): 107-114

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Title

THE EFFECT OF INTRAPERITONEAL INJECTION OF FERULAE ANGULATAHYDROALCOHOLIC EXTRACT ON PENTYLENETETRAZOLE-INDUCED EPILEPSY IN MALE MICE

Author(s)

ETEMADI KERMANI SHOHREH | RAFIEE RAD MARYAM | Issue Writer Certificate

Keywords

FERULAGOANGULATAQ1

PENTYLENETETRAZOLEQ2

DIAZEPAMQ3

EPILEPSYQ2

MICEQ3

Abstract

Background and Objectives: Seizure is one of the most common symptoms of EPILEPSY caused by abnormal electrical activity of neurons; Because of the side effects of chemical drugs the use of herbal medicines can be a good alternative to seizure control. In this study the effectiveness of FERULAGOANGULATA (Schlecht, Boisss) hydroalcoholic extract was investigated in PENTYLENETETRAZOLE (PTZ) -induced seizure in male MICE.Subjects and Methods: In this experimental study, 48 male MICE weighing 25-30g were divided into 6 groups': saline; positive control group (received DIAZEPAM as standard an anticonvulsant drug at 1 mg/Kg) and 4 experimental groups (100, 200, 400, 800 mg/Kg of extract) respectively. All the animal groups received intraperitoneallypentylenetrazole (85 mg/Kg), 30 minutes after appropriate treatment protocol.Results: Injection of FERULAGOANGULATA hydroalcoholic extract delayed the onset of seizure at 400 dose (P<0.001), and reduced the duration of clonic seizure, which had the highest effect in doses of 200 and 400 mg/kg P<0.01 and P<0.001 respectively. Also, administration of hydroalcoholic extract of FERULAGOANGULATAcaused a decrease in the duration of tonic-clonic and decreased the total duration of seizure in animals. DIAZEPAM improved seizures in all cases. The dosage of 200 and 400 mg of extract was similar to DIAZEPAM.Conclusion: In general, intraperitoneal injection of Ferulagohydroalcoholic extract causes delay in attacks in various phases of seizureand it seems the future studies will be necessary to separate its ingredients and understand its mechanism of action.

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References

Metabolic Products of Linalool and Modulation of GABAA Receptors

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APA: Copy

ETEMADI KERMANI, SHOHREH, & RAFIEE RAD, MARYAM. (2018). THE EFFECT OF INTRAPERITONEAL INJECTION OF FERULAE ANGULATAHYDROALCOHOLIC EXTRACT ON PENTYLENETETRAZOLE-INDUCED EPILEPSY IN MALE MICE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 17(1 ), 107-114. SID. https://sid.ir/paper/12327/en

Vancouver: Copy

ETEMADI KERMANI SHOHREH, RAFIEE RAD MARYAM. THE EFFECT OF INTRAPERITONEAL INJECTION OF FERULAE ANGULATAHYDROALCOHOLIC EXTRACT ON PENTYLENETETRAZOLE-INDUCED EPILEPSY IN MALE MICE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2018;17(1 ):107-114. Available from: https://sid.ir/paper/12327/en

IEEE: Copy

SHOHREH ETEMADI KERMANI, and MARYAM RAFIEE RAD, “THE EFFECT OF INTRAPERITONEAL INJECTION OF FERULAE ANGULATAHYDROALCOHOLIC EXTRACT ON PENTYLENETETRAZOLE-INDUCED EPILEPSY IN MALE MICE,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 17, no. 1 , pp. 107–114, 2018, [Online]. Available: https://sid.ir/paper/12327/en

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