COMPARISSON OF THE ANALGESIC EFFECT OF MELISSA OFFICNALLIS EXTRACT WITH ACETYL SALYCILIC ACID AND MORPHINE BY FORMALIN TEST IN MICE

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HEIDARI M.R.; ZAHEDI M.J.; ASKARI A.A.H.

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Journal: Jundishapur Scientific Medical Journal Year:2001 | Volume:- | Issue:29 Page(s): 35-42

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Title

COMPARISSON OF THE ANALGESIC EFFECT OF MELISSA OFFICNALLIS EXTRACT WITH ACETYL SALYCILIC ACID AND MORPHINE BY FORMALIN TEST IN MICE

Author(s)

HEIDARI M.R. | ZAHEDI M.J. | ASKARI A.A.H. | Issue Writer Certificate

Keywords

MELISSA OFFICINALLISQ3

PAIN MEASUREMENTQ2

FORMALIN TESTQ3

ACETYL SALYCILIC ACIDQ3

MORPHINEQ3

MICEQ3

Abstract

Bibliographical studies on traditional plants indicate that there are some evidence for their application as analgesis. In this research, Lemon Balm or MELISSA OFFICINALLIS (MO) was selected for studying the analgesic effects by FORMALIN TEST in MICE. After collection and scientific identification, the leaves and flowered branches of MO were used for extraction in both, percolation and suxhelet methods. Fifty six male MICE weighing 20-25 grams and aging 4-6 week, were used in this study. Methanolic extract resulting from percolation method at different doses; 50, 75,100 and 200 mg/kg and also 200mg/kg of suxhelet extract were injected intraperitoneally to MICE 15 min before formalin injection. Ten ml/kg of vehicle or 300 mg/kg of acetyl salicylic acid (ASA) or 2.5 mg/kg of MORPHINE were injected to the control groups, 15 min before an injection of 0.5% formalin (0.25 µl, S.c. subplantar of leg). The results showed that all doses of extract had a significant analgesic effect as comparing to vehicle (P<0.05) and at the dose of 200 mg/kg had the highest analgesic effect. Moreover percolation extract (200 mg/kg) induced analgesic respones more than suxhelet extract. The analgesic effect of extracts was lower than MORPHINE at all doses. The extract also showed a greater analgesic effect than ASA 5-10 after injection.

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APA: Copy

HEIDARI, M.R., ZAHEDI, M.J., & ASKARI, A.A.H.. (2001). COMPARISSON OF THE ANALGESIC EFFECT OF MELISSA OFFICNALLIS EXTRACT WITH ACETYL SALYCILIC ACID AND MORPHINE BY FORMALIN TEST IN MICE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, -(29), 35-42. SID. https://sid.ir/paper/12402/en

Vancouver: Copy

HEIDARI M.R., ZAHEDI M.J., ASKARI A.A.H.. COMPARISSON OF THE ANALGESIC EFFECT OF MELISSA OFFICNALLIS EXTRACT WITH ACETYL SALYCILIC ACID AND MORPHINE BY FORMALIN TEST IN MICE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2001;-(29):35-42. Available from: https://sid.ir/paper/12402/en

IEEE: Copy

M.R. HEIDARI, M.J. ZAHEDI, and A.A.H. ASKARI, “COMPARISSON OF THE ANALGESIC EFFECT OF MELISSA OFFICNALLIS EXTRACT WITH ACETYL SALYCILIC ACID AND MORPHINE BY FORMALIN TEST IN MICE,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. -, no. 29, pp. 35–42, 2001, [Online]. Available: https://sid.ir/paper/12402/en

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