ANTINOCICEPTIVE EFFECT OF CHAMOMILL ON FORMALIN INDUCED PAIN IN RAT

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VAHIDI A.; DASHTI M.H.; JAMALADDINI S.H.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2001 | Volume:9 | Issue:2 Page(s): 60-65

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Information Journal Paper

Title

ANTINOCICEPTIVE EFFECT OF CHAMOMILL ON FORMALIN INDUCED PAIN IN RAT

Author(s)

VAHIDI A. | DASHTI M.H. | JAMALADDINI S.H. | Issue Writer Certificate

Keywords

CHAMOMILLQ4

PAINQ4

RATQ4

Abstract

Herbal medications are used for traditional treatment of many diseases since the old time. This type of medication has been continued and emphasized up to now. One of the harbal medication classes is the one related to PAIN inhibition. One of those, which is called CHAMOMILL in Iranian traditional medicine has been prescribed as an anti - nociceptive and anti spasmatic drug. In this study, we assessed the effect of this plant on PAIN which was induced by formalin in RAT. CHAMOMILL extract in different concentrations (1,2ml/kg diluted in 1 ml normal saline) were injected intraperitoneally. After fifteen minutes, 50 ml of 2.5% formalin injected subcutaneously into the right limbs. PAIN score was made for 1 hour following the injection of formalin. For PAIN assessment, we used the classic formalin test in which the PAIN score is RATed from zero to three. When no response was observed, the score would be zero. Score 1 is for the time when RAT would not press on its right hind limb. When RAT does not put the injected limb on the ground, score 2 is given and finally if the animal shakes, the injected limb was considered as score 3. Then, the average PAIN score was calculated for each five minutes block up to one hour after formalin injection. Data obtained from 2 test groups and 1 control group (recieving 1 ml normal saline I.P) were tested by ANOVA followed by Newman - keuls. Results showed that 2ml/kl CHAMOMILL antract induced a significant analgesic effect during one hour post formalin injection as compared with control group P<0.001. This analgesic effect in second phase of formalin test (25-60 min, P=0.0008) was more prominent than the first phase (First 5 min., P=0.17). Our data showed that CHAMOMILL extract attenuated PAIN score in a dose dependent manner which was significantly different from that of the control.

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APA: Copy

VAHIDI, A., DASHTI, M.H., & JAMALADDINI, S.H.. (2001). ANTINOCICEPTIVE EFFECT OF CHAMOMILL ON FORMALIN INDUCED PAIN IN RAT . JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 9(2), 60-65. SID. https://sid.ir/paper/36672/en

Vancouver: Copy

VAHIDI A., DASHTI M.H., JAMALADDINI S.H.. ANTINOCICEPTIVE EFFECT OF CHAMOMILL ON FORMALIN INDUCED PAIN IN RAT . JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;9(2):60-65. Available from: https://sid.ir/paper/36672/en

IEEE: Copy

A. VAHIDI, M.H. DASHTI, and S.H. JAMALADDINI, “ANTINOCICEPTIVE EFFECT OF CHAMOMILL ON FORMALIN INDUCED PAIN IN RAT ,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 2, pp. 60–65, 2001, [Online]. Available: https://sid.ir/paper/36672/en

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