EFFECT OF VITAMIN E ON GLUTAMATE RELEASE IN STRIATUM AND MUSCULAR STIFFNESS IN ANIMAL MODEL OF PARKINSON'S DISEASE

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BADVI M.; SARKAKI A.R.; GOODARZVAND K.

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Journal: Jundishapur Scientific Medical Journal Year:2006 | Volume:5 | Issue:3 (50) Page(s): 614-620

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Title

EFFECT OF VITAMIN E ON GLUTAMATE RELEASE IN STRIATUM AND MUSCULAR STIFFNESS IN ANIMAL MODEL OF PARKINSON'S DISEASE

Author(s)

BADVI M. | SARKAKI A.R. | GOODARZVAND K. | Issue Writer Certificate

Keywords

PARKINSON'S DISEASEQ2

GLUTAMATEQ2

VITAMIN EQ3

MUSCULAR STIFFNESSQ3

MICRODIALYSISQ3

RATQ2

Abstract

Objective: PARKINSON'S DISEASE is an age-dependent and a progressive disease due to degeneration of dopaminergic neurons of nigrostriatal system. Increases in the activity of GLUTAMATErgic system and GLUTAMATE concentration in the brain are implicated as factors in development of this disease. Considering the role of free radicals and oxidative factors in the production of GLUTAMATE metabolites, a great deal of researches has been focused on the effects of antioxidative agents in the control of this disease. The main objective of this study was, therefore, to evaluate the effect of intraperitoneal injection of VITAMIN E on GLUTAMATE release in striatum and MUSCULAR STIFFNESS in animal model of PARKINSON'S DISEASE, using MICRODIALYSIS and Morpurgo's test, respectively.Materials and Methods: Male Wistar RATs, weighting 230-280g, were divided into two, treatment and control groups. MICRODIALYSIS probe was implanted in the striatum of all animals. Treatment group was further divided into 4 subgroups; lesioned (with 8 mg/4ml 6-Hydroxy dopamin HCl in substantia nigra), sham-treated (received seasam oil), treatment-1(received 100 mg/Kg vit E) and treatment-2 (received 200 mg/Kg vit E). MICRODIALYSIS was performed by perfusion of artificial cerebrospinal fluid (ACSF) through MICRODIALYSIS probe, and the GLUTAMATE was measured using HPLC equipped with fluorometric detector. Morpurgo's test was performed before and 2 weeks after treatment in all groups.Results: The results of this study have shown that 100 mg/Kg, vit E had no significant effect on GLUTAMATE release, but significantly decreased the MUSCULAR STIFFNESS (p<0.001). However, in 200 mg/Kg, vit E-treated group, both the level of GLUTAMATE released (p<0.02) and the MUSCULAR STIFFNESS (p<0.001) were decreased significantly.Conclusion: These results indicate that vit E decreases, possibly through its antioxidative property, GLUTAMATE release and also reduces MUSCULAR STIFFNESS in this experimental animal model of PARKINSON'S DISEASE.

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APA: Copy

BADVI, M., SARKAKI, A.R., & GOODARZVAND, K.. (2006). EFFECT OF VITAMIN E ON GLUTAMATE RELEASE IN STRIATUM AND MUSCULAR STIFFNESS IN ANIMAL MODEL OF PARKINSON'S DISEASE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 5(3 (50)), 614-620. SID. https://sid.ir/paper/12548/en

Vancouver: Copy

BADVI M., SARKAKI A.R., GOODARZVAND K.. EFFECT OF VITAMIN E ON GLUTAMATE RELEASE IN STRIATUM AND MUSCULAR STIFFNESS IN ANIMAL MODEL OF PARKINSON'S DISEASE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2006;5(3 (50)):614-620. Available from: https://sid.ir/paper/12548/en

IEEE: Copy

M. BADVI, A.R. SARKAKI, and K. GOODARZVAND, “EFFECT OF VITAMIN E ON GLUTAMATE RELEASE IN STRIATUM AND MUSCULAR STIFFNESS IN ANIMAL MODEL OF PARKINSON'S DISEASE,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 5, no. 3 (50), pp. 614–620, 2006, [Online]. Available: https://sid.ir/paper/12548/en

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