THE EXPRESSION LEVELS OF RAD51 AFTER IONIZING RADIATION IN PERIPHERAL BLOOD LYMPHOCYTES FOR EVALUATION OF DNA REPAIR IN BREAST CANCER PATIENTS REFERRED TO AHVAZ GOLESTAN HOSPITAL

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HOSSEIN SABERI SEYED ALI; SHAFIEE MOHSEN; HUSSEINI SEYED MOHAMMAD; LATIFI SEYED MAHMOUD

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Journal: Jundishapur Scientific Medical Journal Year:2013 | Volume:12 | Issue:3 (84) Page(s): 299-306

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Title

THE EXPRESSION LEVELS OF RAD51 AFTER IONIZING RADIATION IN PERIPHERAL BLOOD LYMPHOCYTES FOR EVALUATION OF DNA REPAIR IN BREAST CANCER PATIENTS REFERRED TO AHVAZ GOLESTAN HOSPITAL

Author(s)

HOSSEIN SABERI SEYED ALI | SHAFIEE MOHSEN | HUSSEINI SEYED MOHAMMAD | LATIFI SEYED MAHMOUD | Issue Writer Certificate

Keywords

RAD51Q2

GENE EXPRESSIONQ3

BREAST CANCERQ2

RADIOTHERAPYQ1

RADIO SENSITIVITYQ3

Abstract

Background and Objective: BREAST CANCER is one of the most common cancers among the women. One of the radical methods for treatment of BREAST CANCER is RADIOTHERAPY. Radiation induces different responses in cells, including cell cycle checkpoint activation, DNA repair and apoptosis. To check cellular responses and RADIO SENSITIVITY in each patient, DNA repair mechanism and proteins, as biological markers, can be evaluated. Based on the repair capacity and RADIO SENSITIVITY of cells in each patient we can design a treatment planning using radiation therapy The purpose of this study was to evaluate to the RADIO SENSITIVITY in BREAST CANCER patients to improve treatment planning.Subjects and Methods: A quantitative reverse transcriptase PCR-based assay for measurement of the expression level of RAD51 in lymphocyte cells for all BREAST CANCER patients and healthy controls. Statistical analyses were performed using SPSS17 software. The relation between the expression level of RAD51and clinical characteristics of patients was analyzed by using the nonparametric Mann-Whitney and Kruskal-Wallis tests.Results: The expression level of RAD51 significantly up regulated in the peripheral blood lymphocytes of patients (P=0.006, 8 Fold change) compared to healthy controls. A significant correlation between the expression level of RAD51 and HER2/neu (P=0.024) as well as patients age (P=0.03).Conclusion: Expression level of RAD51 in lymphocyte cells can be a useful biological marker for evaluation of RADIO SENSITIVITY in BREAST CANCER.

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APA: Copy

HOSSEIN SABERI, SEYED ALI, SHAFIEE, MOHSEN, HUSSEINI, SEYED MOHAMMAD, & LATIFI, SEYED MAHMOUD. (2013). THE EXPRESSION LEVELS OF RAD51 AFTER IONIZING RADIATION IN PERIPHERAL BLOOD LYMPHOCYTES FOR EVALUATION OF DNA REPAIR IN BREAST CANCER PATIENTS REFERRED TO AHVAZ GOLESTAN HOSPITAL. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 12(3 (84)), 299-306. SID. https://sid.ir/paper/12758/en

Vancouver: Copy

HOSSEIN SABERI SEYED ALI, SHAFIEE MOHSEN, HUSSEINI SEYED MOHAMMAD, LATIFI SEYED MAHMOUD. THE EXPRESSION LEVELS OF RAD51 AFTER IONIZING RADIATION IN PERIPHERAL BLOOD LYMPHOCYTES FOR EVALUATION OF DNA REPAIR IN BREAST CANCER PATIENTS REFERRED TO AHVAZ GOLESTAN HOSPITAL. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2013;12(3 (84)):299-306. Available from: https://sid.ir/paper/12758/en

IEEE: Copy

SEYED ALI HOSSEIN SABERI, MOHSEN SHAFIEE, SEYED MOHAMMAD HUSSEINI, and SEYED MAHMOUD LATIFI, “THE EXPRESSION LEVELS OF RAD51 AFTER IONIZING RADIATION IN PERIPHERAL BLOOD LYMPHOCYTES FOR EVALUATION OF DNA REPAIR IN BREAST CANCER PATIENTS REFERRED TO AHVAZ GOLESTAN HOSPITAL,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 12, no. 3 (84), pp. 299–306, 2013, [Online]. Available: https://sid.ir/paper/12758/en

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