RAD51 135G>C POLYMORPHISM AND BREAST CANCER RISK IN WOMEN OF NORTHWEST IRAN

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FARIDI SONIA; ZEINALZADEH NARGES; HOSSEINPOUR FEIZI MOHAMMAD ALI; POULADI NASSER

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Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:2 Page(s): 167-172

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Title

RAD51 135G>C POLYMORPHISM AND BREAST CANCER RISK IN WOMEN OF NORTHWEST IRAN

Author(s)

FARIDI SONIA | ZEINALZADEH NARGES | HOSSEINPOUR FEIZI MOHAMMAD ALI | POULADI NASSER | Issue Writer Certificate

Keywords

AZERI-TURKISHQ1

BREAST CANCERQ1

IRANQ1

RAD51 135G > C POLYMORPHISMQ2

Abstract

Breast cancer is one of the main causes of death among IRANian women. Human RAD51 protein plays a central role in homologous recombination repair of double-stranded DNA breaks and is essential for maintaining genomic stability. Asingle nucleotide polymorphism in the 5′-untranslated region of RAD51 gene (RAD51 135G˃C) is reported to modulate BREAST CANCER risk. The aim of this study was to find out the relationship of this SNP with BREAST CANCER risk among IRANian Azeri Turkish women.Materials and Methods This case-control study was performed on 127 BREAST CANCER cases and 125 controls. Genomic DNA was extracted and the RAD51 135G>C genotype was determined using a PCR–Restriction Fragment Length Polymorphism (RFLP) based assay and confirmed by sequencing. The results were analyzed statistically.Results The frequencies of CC, CG and GG genotypes of RAD51 135G˃C were 1.613%, 20.161% and 78.225% in control group and 2.362%, 24.409% and 73.228% in patients, respectively. The results showed no significant differences among patients and controls groups.Conclusion The data presented here may suggest that the RAD51 135G>C polymorphism is not associated with BREAST CANCER risk in IRANian Azeri population.

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APA: Copy

FARIDI, SONIA, ZEINALZADEH, NARGES, HOSSEINPOUR FEIZI, MOHAMMAD ALI, & POULADI, NASSER. (2018). RAD51 135G>C POLYMORPHISM AND BREAST CANCER RISK IN WOMEN OF NORTHWEST IRAN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(2 ), 167-172. SID. https://sid.ir/paper/81791/en

Vancouver: Copy

FARIDI SONIA, ZEINALZADEH NARGES, HOSSEINPOUR FEIZI MOHAMMAD ALI, POULADI NASSER. RAD51 135G>C POLYMORPHISM AND BREAST CANCER RISK IN WOMEN OF NORTHWEST IRAN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(2 ):167-172. Available from: https://sid.ir/paper/81791/en

IEEE: Copy

SONIA FARIDI, NARGES ZEINALZADEH, MOHAMMAD ALI HOSSEINPOUR FEIZI, and NASSER POULADI, “RAD51 135G>C POLYMORPHISM AND BREAST CANCER RISK IN WOMEN OF NORTHWEST IRAN,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 2 , pp. 167–172, 2018, [Online]. Available: https://sid.ir/paper/81791/en

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