VIRUS-LIKE PARTICLE: STRUCTURE, CHARACTERISTICS AND APPLICATION INVACCINE

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HOSSEINI SEYED AMIR; EBRAHIMI FIROUZ; SAADATI MOJTABA; FATHI JAVAD

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Journal: Jundishapur Scientific Medical Journal Year:2017 | Volume:16 | Issue:5 Page(s): 575-589

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Title

VIRUS-LIKE PARTICLE: STRUCTURE, CHARACTERISTICS AND APPLICATION INVACCINE

Author(s)

HOSSEINI SEYED AMIR | EBRAHIMI FIROUZ | SAADATI MOJTABA | FATHI JAVAD | Issue Writer Certificate

Keywords

VIRUS-LIKE PARTICLESQ1

EXPRESSION SYSTEMSQ2

VACCINEQ1

IMMUNOGENICITYQ2

Abstract

VIRUS-LIKE PARTICLES (VLPs) are a group of subunit VACCINEs, which due to a stronger protective IMMUNOGENICITY, aredistinguished from soluble recombinant antigens. Like nativeviruses, VIRUS-LIKE PARTICLES can be both enveloped and nonenveloped. They are formed from the expression of one or moreviral structural proteins in a heterologous system. Depending onthe complexity of the VLP, the proteins can be produced inprokaryotic or eukaryotic EXPRESSION SYSTEMS, or in certaincases, they can be manufactured and assembled in the cell-freeconditions. VIRUS-LIKE PARTICLES can be produced in a range ofcell culture systems, including mammalian cell lines, insectcells, yeast, plant cells and cell-free conditions. To date, a widerange of VLP-based VACCINE candidates against viral, bacterial, parasitic, and fungal pathogens, as well as non-infectiousdiseases, have been produced in various EXPRESSION SYSTEMS. Some of VLPs have entered clinical development and few ofthem have licensed and commercialized.

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APA: Copy

HOSSEINI, SEYED AMIR, EBRAHIMI, FIROUZ, SAADATI, MOJTABA, & FATHI, JAVAD. (2017). VIRUS-LIKE PARTICLE: STRUCTURE, CHARACTERISTICS AND APPLICATION INVACCINE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 16(5 ), 575-589. SID. https://sid.ir/paper/12977/en

Vancouver: Copy

HOSSEINI SEYED AMIR, EBRAHIMI FIROUZ, SAADATI MOJTABA, FATHI JAVAD. VIRUS-LIKE PARTICLE: STRUCTURE, CHARACTERISTICS AND APPLICATION INVACCINE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2017;16(5 ):575-589. Available from: https://sid.ir/paper/12977/en

IEEE: Copy

SEYED AMIR HOSSEINI, FIROUZ EBRAHIMI, MOJTABA SAADATI, and JAVAD FATHI, “VIRUS-LIKE PARTICLE: STRUCTURE, CHARACTERISTICS AND APPLICATION INVACCINE,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 16, no. 5 , pp. 575–589, 2017, [Online]. Available: https://sid.ir/paper/12977/en

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