CYTOTOXIC EFFECT OF HYDROALCHOLIC EXTRACTS OF KELUSSIA ODARATISSMA MOZAFF AND THYMUS DAENESIS CELAK ON MCF-7 CANCER CELL LINE

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SADEGHI SAMANI FATEMEH; SAZEGAR HOSEEIN; GHASEMI PIRBALOUTI ABDOLLAH

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Journal: Pars Journal of Medical Sciences Year:2016 | Volume:14 | Issue:2 Page(s): 59-67

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Title

CYTOTOXIC EFFECT OF HYDROALCHOLIC EXTRACTS OF KELUSSIA ODARATISSMA MOZAFF AND THYMUS DAENESIS CELAK ON MCF-7 CANCER CELL LINE

Author(s)

SADEGHI SAMANI FATEMEH | SAZEGAR HOSEEIN | GHASEMI PIRBALOUTI ABDOLLAH | Issue Writer Certificate

Keywords

KELUSSIA ODARATISSMA MOZAFFQ1

THYMUS DAENESIS CELAKQ2

MCF-7Q2

MTT ASSAYQ2

Abstract

Introduction: Breast cancer is the second most common cancer after lung cancer in women. Given that herbal preparations have long been used to treat cancer, this study aimed to investigate the cytotoxic effect of hydroalcholic extract of KELUSSIA ODARATISSMA MOZAFF and THYMUS DAENESIS CELAK on MCF-7 cancer cell line.Materials and methods: MCF-7 cancer cells and normal fibroblasts were cultured in DMEM medium containing Fetal Bovine Serum (FBS) and antibiotic. The cells were exposed to different doses of hydroalcholic extract of KELUSSIA ODARATISSMA MOZAFF and THYMUS DAENESIS CELAK (0.156, 0.312, 0.625, 1.25, 2.5 mg/ml) and were incubated for 24, 48 and 72 hours. After the incubation period, modified colorimetric MTT method was used to determine the cellular toxicity of the extract.Results: The results of the MTT test showed that hydroalcholic extract of KELUSSIA ODARATISSMA MOZAFF and THYMUS DAENESIS CELAK had dose-dependent and time-dependent anti-cancer effect on MCF-7 cancer cells. The highest percentage of cell death was observed with the highest concentration of the extract and after 72 h of incubation (p<0.05). The extract did not show significant cytotoxicity on normal fibroblasts.Conclusion: Hydroalcholic extract of KELUSSIA ODARATISSMA MOZAFF and THYMUS DAENESIS CELAK has cytotoxic effects on MCF-7 cancer cells; however, this extract does not have any cytotoxic effects on normal fibroblasts. It appears that this extract can be used for cancer treatment with further research.

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APA: Copy

SADEGHI SAMANI, FATEMEH, SAZEGAR, HOSEEIN, & GHASEMI PIRBALOUTI, ABDOLLAH. (2016). CYTOTOXIC EFFECT OF HYDROALCHOLIC EXTRACTS OF KELUSSIA ODARATISSMA MOZAFF AND THYMUS DAENESIS CELAK ON MCF-7 CANCER CELL LINE. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 14(2), 59-67. SID. https://sid.ir/paper/130852/en

Vancouver: Copy

SADEGHI SAMANI FATEMEH, SAZEGAR HOSEEIN, GHASEMI PIRBALOUTI ABDOLLAH. CYTOTOXIC EFFECT OF HYDROALCHOLIC EXTRACTS OF KELUSSIA ODARATISSMA MOZAFF AND THYMUS DAENESIS CELAK ON MCF-7 CANCER CELL LINE. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2016;14(2):59-67. Available from: https://sid.ir/paper/130852/en

IEEE: Copy

FATEMEH SADEGHI SAMANI, HOSEEIN SAZEGAR, and ABDOLLAH GHASEMI PIRBALOUTI, “CYTOTOXIC EFFECT OF HYDROALCHOLIC EXTRACTS OF KELUSSIA ODARATISSMA MOZAFF AND THYMUS DAENESIS CELAK ON MCF-7 CANCER CELL LINE,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 14, no. 2, pp. 59–67, 2016, [Online]. Available: https://sid.ir/paper/130852/en

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