PROTECTIVE EFFECTS OF SOPHORAPACHYCARPAROOT EXTRACT AGAINST CCL4- INDUCED NEPHROTOXICITY IN MALE RATS

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BANAN KHOJASTEH SEYED MAHDI; HOURESFAND MARYAM; JAVANMARD KHAMENEH REIHANEH; YALDAGARD ELHAM

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2017 | Volume:11 | Issue:2 Page(s): 29-37

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Title

PROTECTIVE EFFECTS OF SOPHORAPACHYCARPAROOT EXTRACT AGAINST CCL4- INDUCED NEPHROTOXICITY IN MALE RATS

Author(s)

BANAN KHOJASTEH SEYED MAHDI | HOURESFAND MARYAM | JAVANMARD KHAMENEH REIHANEH | YALDAGARD ELHAM | Issue Writer Certificate

Keywords

SOPHORA PACHYCARPAQ1

CARBON TETRACHLORIDEQ2

NEPHROTOXICITYQ1

RATQ2

Abstract

Background and Objectives: CARBON TETRACHLORIDE (CCl4) causes damage in liver, kidneys, lungs, testis, brain, and blood through generation of free radicals. The purpose of this study was to investigate the protective effects of SOPHORA PACHYCARPA root extract on CCl4-induced NEPHROTOXICITY in male RATs.Methods: In this experimental study, 36 male RATs (weight range, 195-200 g) were randomly divided into 6 groups of 6 each: Pre-treatment groups 1, 2, and 3) at doses of 50, 100, and 250 mg/kg), control group, CCl4 group, and post-treatment group. At the end of the treatment period, serum levels of creatinine, total protein, and albumin, were measured. Then, the kidneys were removed from the animal’s body for histological examination.Results: Injection of CCl4 to the RATs significantly increased the serum level of creatinine compared to the control group, while decreased the serum levels of albumin and total protein. Also, treatment with S. pachycarpa root extracts significantly reversed the aforementioned changes to normal levels. Treatment with the extract (250 mg/kg) led to remarkable improvement in histopathological changes of kidney sections.Conclusion: The results of this study indicated that S. pachycarpa extract can partly moderate the toxic effects of CCl4 in kidney, which is possibly due to the presence of its bioactive compounds.

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References

PHARMACOLOGY OF FREE RADICALS AND THE IMPACT OF REACTIVE OXYGEN SPECIES ON THE TESTIS

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APA: Copy

BANAN KHOJASTEH, SEYED MAHDI, HOURESFAND, MARYAM, JAVANMARD KHAMENEH, REIHANEH, & YALDAGARD, ELHAM. (2017). PROTECTIVE EFFECTS OF SOPHORAPACHYCARPAROOT EXTRACT AGAINST CCL₄- INDUCED NEPHROTOXICITY IN MALE RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 11(2), 29-37. SID. https://sid.ir/paper/132131/en

Vancouver: Copy

BANAN KHOJASTEH SEYED MAHDI, HOURESFAND MARYAM, JAVANMARD KHAMENEH REIHANEH, YALDAGARD ELHAM. PROTECTIVE EFFECTS OF SOPHORAPACHYCARPAROOT EXTRACT AGAINST CCL₄- INDUCED NEPHROTOXICITY IN MALE RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2017;11(2):29-37. Available from: https://sid.ir/paper/132131/en

IEEE: Copy

SEYED MAHDI BANAN KHOJASTEH, MARYAM HOURESFAND, REIHANEH JAVANMARD KHAMENEH, and ELHAM YALDAGARD, “PROTECTIVE EFFECTS OF SOPHORAPACHYCARPAROOT EXTRACT AGAINST CCL₄- INDUCED NEPHROTOXICITY IN MALE RATS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 11, no. 2, pp. 29–37, 2017, [Online]. Available: https://sid.ir/paper/132131/en

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