The Effect of Punica granatum (Pomegranate) Extract on Inflammatory Biomarkers, Lipid Profile, and Glycemic Indices in Patients with Overweight and Obesity: Randomized Clinical Trial

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Zarezadeh Meysam; SAEDISOMEOLIA AHMAD; HOSSEINI BANAFSHEH; EMAMI MOHAMMAD REZA

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2019 | Volume:13 | Issue:8 Page(s): 14-25

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Title

The Effect of Punica granatum (Pomegranate) Extract on Inflammatory Biomarkers, Lipid Profile, and Glycemic Indices in Patients with Overweight and Obesity: Randomized Clinical Trial

Author(s)

Zarezadeh Meysam | SAEDISOMEOLIA AHMAD | HOSSEINI BANAFSHEH | EMAMI MOHAMMAD REZA | Issue Writer Certificate

Keywords

PunicaceaeQ1

ObesityQ2

InflammationQ2

Lipid peroxidationQ1

Randomized clinical trialQ2

Abstract

Background and Objectives: In various studies, different antioxidant effects of pomegranate extract, have been reported. The objective of this study was to determine the effect of 30-day oral supplementation with pomegranate extract on inflammatory markers, blood lipids, and glycemic indices in overweight and obese individuals. Methods: In this randomized, double-blind, placebo-controlled study, 48 obese and overweight participants, were randomly selected from adult individuals aged 30-60 years with body mass index (BMI) of 25-40 (to receive either 1000mg of pomegranate extract or a placebo for 30 days). At baseline and after 30 days of treatment, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde (MDA), interleukin-6 (IL-6), and hyper sensitive C-reactive protein (hs-CRP) and the levels of serum lipids, glucose, and insulin were assessed. Data were analyzed using independent and dependent t-tests. Results: In this study, 30 days of supplementation with pomegranate extract resulted in a significant decrease in mean serum levels of glucose, insulin, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and plasma MDA, IL-6, and hs-CRP. Moreover, highdensity lipoprotein cholesterol (HDL-C) significantly increased following supplementation with pomegranate extract compared to the placebo group. Conclusion: supplementation with pomegranate extract can be effective in the reduction of Obesity and overweight related complications through ameliorating the systemic Inflammation and lipid profile. Therefore, future studies with larger sample size are required to prove these results.

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APA: Copy

Zarezadeh, Meysam, SAEDISOMEOLIA, AHMAD, HOSSEINI, BANAFSHEH, & EMAMI, MOHAMMAD REZA. (2019). The Effect of Punica granatum (Pomegranate) Extract on Inflammatory Biomarkers, Lipid Profile, and Glycemic Indices in Patients with Overweight and Obesity: Randomized Clinical Trial. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 13(8 ), 14-25. SID. https://sid.ir/paper/132310/en

Vancouver: Copy

Zarezadeh Meysam, SAEDISOMEOLIA AHMAD, HOSSEINI BANAFSHEH, EMAMI MOHAMMAD REZA. The Effect of Punica granatum (Pomegranate) Extract on Inflammatory Biomarkers, Lipid Profile, and Glycemic Indices in Patients with Overweight and Obesity: Randomized Clinical Trial. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2019;13(8 ):14-25. Available from: https://sid.ir/paper/132310/en

IEEE: Copy

Meysam Zarezadeh, AHMAD SAEDISOMEOLIA, BANAFSHEH HOSSEINI, and MOHAMMAD REZA EMAMI, “The Effect of Punica granatum (Pomegranate) Extract on Inflammatory Biomarkers, Lipid Profile, and Glycemic Indices in Patients with Overweight and Obesity: Randomized Clinical Trial,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 13, no. 8 , pp. 14–25, 2019, [Online]. Available: https://sid.ir/paper/132310/en

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