Effect of Artemisia persica Essential Oil on Memory Deficits, Depression, and Anxiety in Pentylenetetrazole (PTZ) Kindled Male Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Daneshkhah Mozhgan; SETORKI MAHBUBEH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2019 | Volume:13 | Issue:8 Page(s): 33-41

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

460

Download:

Cites:

Information Journal Paper

Title

Effect of Artemisia persica Essential Oil on Memory Deficits, Depression, and Anxiety in Pentylenetetrazole (PTZ) Kindled Male Mice

Author(s)

Daneshkhah Mozhgan | SETORKI MAHBUBEH | Issue Writer Certificate

Keywords

MemoryQ2

DepressionQ2

AnxietyQ2

PentylenetetrazoleQ1

Artemisia persicaQ1

Abstract

Background and Objectives: Epilepsy is the most common neurological disorder after a stroke, which causes recurrent seizures. The aim of the present study was to evaluate Memory deficits and mood disorders, such as Depression and Anxiety are commonly seen in patients with epilepsy. The aim of this study was to evaluate the effectiveness of Iranian Artemisia persica essential oil on Memory deficits, Depression, and Anxiety in Pentylenetetrazole (PTZ) kindled male mice. Methods: In this experimental study, 70 male mice, were randomly divided into 7 groups: normal saline group, epilepsy model that received PTZ (35mg/kg) every other day with 48h intervals for 9 day and then the essential (at a dose of 60mg/kg) on the 10th day. treatment groups that received PTZ with 48h intervals and essential oil (at doses of 50, 75, and 100mg/kg) daily, positive control group that received PTZ with 48h intervals and essential oil (dose, 100mg/kg) daily and diazepam on the 10th day, 30 minutes before the injection of PTZ. Flumazenil group received PTZ with 48h intervals and essential oil (dose, 100mg/kg) daily and flumazenil on the 10th day, 30 minutes before the injection of PTZ. One way ANOVA and Tukey tests were used for data analyze. Results: Artemisia persica essential oil (dose, 50mg/kg) caused a significant increased delay in the onset of seizures in the mice that received PTZ (p<0. 05); also, the essential oil at a dose of 50mg/kg significantly decreased secondary latency time in the shuttle box test (p<0. 05). Different doses of Artemisia persica essential oil showed no significant effect on the immobility time in the tail suspension test, and the frequency of entry into the closed arms of the elevated plus maze in the group that received 50mg/kg of Artemisia persica essential oil, was significantly lower than that in the PTZ-treated group (p<0. 05). Conclusion: Iranian Artemisia persica essential oil (at a dose of 50mg/kg) effectively reduced seizure threshold, significantly increased the avoidance Memory, and decreased Anxiety in mice receiving PTZ.

Cites

No record.

References

Cite

APA: Copy

Daneshkhah, Mozhgan, & SETORKI, MAHBUBEH. (2019). Effect of Artemisia persica Essential Oil on Memory Deficits, Depression, and Anxiety in Pentylenetetrazole (PTZ) Kindled Male Mice. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 13(8 ), 33-41. SID. https://sid.ir/paper/132317/en

Vancouver: Copy

Daneshkhah Mozhgan, SETORKI MAHBUBEH. Effect of Artemisia persica Essential Oil on Memory Deficits, Depression, and Anxiety in Pentylenetetrazole (PTZ) Kindled Male Mice. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2019;13(8 ):33-41. Available from: https://sid.ir/paper/132317/en

IEEE: Copy

Mozhgan Daneshkhah, and MAHBUBEH SETORKI, “Effect of Artemisia persica Essential Oil on Memory Deficits, Depression, and Anxiety in Pentylenetetrazole (PTZ) Kindled Male Mice,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 13, no. 8 , pp. 33–41, 2019, [Online]. Available: https://sid.ir/paper/132317/en

Related Journal Papers