THE EFFECT OF ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON PENTYLENETETRAZOL-INDUCED SEIZURE IN MALE MICE

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KESHAVARZIAN M.; VAEZI GH.; HEIDARIEH N.

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2014 | Volume:6 | Issue:4 Page(s): 61-72

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Title

THE EFFECT OF ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON PENTYLENETETRAZOL-INDUCED SEIZURE IN MALE MICE

Author(s)

KESHAVARZIAN M. | VAEZI GH. | HEIDARIEH N. | Issue Writer Certificate

Keywords

SEIZUREQ2

PTZQ2

ARTEMISIA AUCHERIQ2

ACH RESEPTORQ2

CINEOLQ2

SANTONINQ2

CAMPHORQ3

Abstract

Various species of the genus Artemisia are used as drugs in the treatment of some diseases and also in the physiological and pharmacological studies. ARTEMISIA AUCHERI contains large amounts essence of terpenoids group, particularly “sesquiterpene lactones, ketones and monoterpene. These components have biological activities thus they can affect some physiological activites. In this study, the effect of alcoholic extract of ARTEMISIA AUCHERI on pentylenetetrazole (PTZ) induced convulsions was investigated. In this research, N-MRI male mice with weighing (22-28 g) were used. The animals were divided into three groups: control group (saline), Sham group that received saline and Tween 20 (1%), and experimental groups that included three subgroups. In these subgroups, mice were injected 5, 6.25 and 7.5 mg/kg extract respectively. All drugs were injected intraperitoneally. After 20 minutes SEIZURE was induced by pentylenetetrazole (80 mg/kg) and SEIZURE symptoms were evaluated for 20 minutes. Data were analyzed by one- way ANOVA. Our results showed that ARTEMISIA AUCHERI in 7.5 mg/kg dose decreased initiation time in the 2stage and 5 stage (p<0.05). And also this dose increased SEIZURE score in comparison with sham group (p<0.01) and with group that received 5 mg/kg (P <0.05) significantly. Also extract in 6.25 mg/kg (p<0.05) and 7.5 mg/kg (p<0.01) doses increased the number of enterance into stage 5 significantly. On the other hand, death rate increased dose dependently. The results indicated that in vegetative season, alcoholic extract of ARTEMISIA AUCHERI increases PTZ induced convulsions in dose dependent manner. It seems that some substances such as sesquiterpene lactones or some monoterpene ketone such as CAMPHOR and CINEOLe (through reducing catecholamines release by noncompetitive inhibition of nicotinic acetylcholine receptors) cause this situation.

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APA: Copy

KESHAVARZIAN, M., VAEZI, GH., & HEIDARIEH, N.. (2014). THE EFFECT OF ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON PENTYLENETETRAZOL-INDUCED SEIZURE IN MALE MICE. JOURNAL OF ANIMAL BIOLOGY, 6(4), 61-72. SID. https://sid.ir/paper/176949/en

Vancouver: Copy

KESHAVARZIAN M., VAEZI GH., HEIDARIEH N.. THE EFFECT OF ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON PENTYLENETETRAZOL-INDUCED SEIZURE IN MALE MICE. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2014;6(4):61-72. Available from: https://sid.ir/paper/176949/en

IEEE: Copy

M. KESHAVARZIAN, GH. VAEZI, and N. HEIDARIEH, “THE EFFECT OF ALCOHOLIC EXTRACT OF ARTEMISIA AUCHERI ON PENTYLENETETRAZOL-INDUCED SEIZURE IN MALE MICE,” JOURNAL OF ANIMAL BIOLOGY, vol. 6, no. 4, pp. 61–72, 2014, [Online]. Available: https://sid.ir/paper/176949/en

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