THE EFFECTS OF DIFFERENT DOSES OF CURCUMA LONGA AQUEOUS EXTRACT ON MEMORY RETENTION AND RETRIEVAL IN MALE MICE

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CHAVOSHIZADEH SEYED ABDOLLAH; KHORASANI NIASAR NEDA; MOSLEHI AZAM; Farahabadi Mohsen; SARAHVARDI SHADI

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2016 | Volume:10 | Issue:9 Page(s): 12-18

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Title

THE EFFECTS OF DIFFERENT DOSES OF CURCUMA LONGA AQUEOUS EXTRACT ON MEMORY RETENTION AND RETRIEVAL IN MALE MICE

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Keywords

CURCUMAQ2

MEMORY DISORDERSQ1

MEMORY RETRIEVALQ2

PASSIVE AVOIDANCE APPARATUSQ1

MICEQ2

Abstract

Background and Objectives: Curcumin belongs to ginger family, which is used as food and drug from ancient times. Different studies have shown beneficial effects of curcumin on peptic ulcer, rheumatoid arthritis, asthma, and various types of cancer. In this study, the effect of different doses of CURCUMA longa aqueous extract on memory retention and retrieval of MICE, was investigated using PASSIVE AVOIDANCE APPARATUS.Methods: MICE were divided into 6 groups of 8 each for memory retention test and 6 groups of 8 each for MEMORY RETRIEVAL test {experimental groups receiving the extract intraperitoneally at doses of 100, 200, 400, 800 mg/kg, blank group, and control group}. In memory retention test, the curcumin extract was administered immediately after electric shock, while in the MEMORY RETRIEVAL test, it was administered 24 h after receiving electric shock. To compare the complete stepping in the experiment days, One-way ANOVA and post-test LSD were used. The level of significance was considered p<0.05.Results: In this study, CURCUMA longa aqueous extract significantly increased memory retention and retrieval on the 4th day compared to blank and control groups. The best response for memory retention was obtained at the dose of 100mg/kg and for MEMORY RETRIEVAL at the dose of 200mg/kg.Conclusion: According to the results of this study, it seems that CURCUMA longa aqueous extract improves memory retention and retrieval in healthy MICE.

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APA: Copy

CHAVOSHIZADEH, SEYED ABDOLLAH, KHORASANI NIASAR, NEDA, MOSLEHI, AZAM, Farahabadi, Mohsen, & SARAHVARDI, SHADI. (2016). THE EFFECTS OF DIFFERENT DOSES OF CURCUMA LONGA AQUEOUS EXTRACT ON MEMORY RETENTION AND RETRIEVAL IN MALE MICE. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 10(9), 12-18. SID. https://sid.ir/paper/132328/en

Vancouver: Copy

CHAVOSHIZADEH SEYED ABDOLLAH, KHORASANI NIASAR NEDA, MOSLEHI AZAM, Farahabadi Mohsen, SARAHVARDI SHADI. THE EFFECTS OF DIFFERENT DOSES OF CURCUMA LONGA AQUEOUS EXTRACT ON MEMORY RETENTION AND RETRIEVAL IN MALE MICE. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2016;10(9):12-18. Available from: https://sid.ir/paper/132328/en

IEEE: Copy

SEYED ABDOLLAH CHAVOSHIZADEH, NEDA KHORASANI NIASAR, AZAM MOSLEHI, Mohsen Farahabadi, and SHADI SARAHVARDI, “THE EFFECTS OF DIFFERENT DOSES OF CURCUMA LONGA AQUEOUS EXTRACT ON MEMORY RETENTION AND RETRIEVAL IN MALE MICE,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 10, no. 9, pp. 12–18, 2016, [Online]. Available: https://sid.ir/paper/132328/en

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