STUDY OF LIPASE GENES EXPRESSION (LIP2,3,5) IN CANDIDA ALBICANS ISOLATED FROM PATIENTS

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Ghaffari Mansoureh; NOORBAKHSH FATEMEH; KACHUEI REZA

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2017 | Volume:11 | Issue:2 Page(s): 53-60

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Title

STUDY OF LIPASE GENES EXPRESSION (LIP2,3,5) IN CANDIDA ALBICANS ISOLATED FROM PATIENTS

Author(s)

Ghaffari Mansoureh | NOORBAKHSH FATEMEH | KACHUEI REZA | Issue Writer Certificate

Keywords

CANDIDA ALBICANSQ1

LIPASE ENCODING GENESQ2

LIP2Q2

LIP3Q2

LIP5Q2

RTPCRQ2

Abstract

Background and Aims: Candida, is a fungal flora in human that can be colonized on the skin and mucosal surfaces. Various factors are involved in causing disease bycandida, one of the most important of these factors, are secreted hydrolytic enzymes and aspartyl proteinase enzymes are as a potential factor, but other secretion of hydrolytic enzymes such as phospholipase and lipase are also important pathogen factors. In this study, gene expression of LIP2, LIP3and LIP5 were studied in isolated C. albicans in 100 samples from patients.Materials and Methods: A total of 100 strains of C. albicans was isolated in 2015-2016 years by morphology and molecular methods, from clinical samples. After extracting RNA from them by RNX-Plus kit, expression of LIP2, LIP3 and LIP5 genes was evaluated by using RTPCR test.Results: From 100 clinical isolates of C. albicans, LIP2 gene expressed 55%, LIP3 gene 41% andLIP5 gene 48%. Among the positive samples, 24 cases (33.80%) were expressed three genes at the same time.Conclusions: In this study, frequency of lipase genes was different in strains of C.albicans. Lipase gene was not expressed in 30% of cases. It can be concluded that other genes than lipase gene can be involved in the pathogenesis.

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APA: Copy

Ghaffari, Mansoureh, NOORBAKHSH, FATEMEH, & KACHUEI, REZA. (2017). STUDY OF LIPASE GENES EXPRESSION (LIP2,3,5) IN CANDIDA ALBICANS ISOLATED FROM PATIENTS. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 11(2), 53-60. SID. https://sid.ir/paper/132629/en

Vancouver: Copy

Ghaffari Mansoureh, NOORBAKHSH FATEMEH, KACHUEI REZA. STUDY OF LIPASE GENES EXPRESSION (LIP2,3,5) IN CANDIDA ALBICANS ISOLATED FROM PATIENTS. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2017;11(2):53-60. Available from: https://sid.ir/paper/132629/en

IEEE: Copy

Mansoureh Ghaffari, FATEMEH NOORBAKHSH, and REZA KACHUEI, “STUDY OF LIPASE GENES EXPRESSION (LIP2,3,5) IN CANDIDA ALBICANS ISOLATED FROM PATIENTS,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 11, no. 2, pp. 53–60, 2017, [Online]. Available: https://sid.ir/paper/132629/en

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