DETECTION OF BLADIM, BLAAIM, BLAGIM, BLANDM AND BLAVIM GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN TEHRAN HOSPITALS, IRAN

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GOUDARZI HOSSEIN; HASHEMI ALI; FALLAH FATEMEH; NOORI MARYAM; ERFANIMANESH SOROOR; YOUSEFI NEDA; HEIDARY MOHSEN; KHOSHNOOD SAEED; HOURI HAMIDREZA

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2016 | Volume:9 | Issue:4 Page(s): 32-39

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Title

DETECTION OF BLADIM, BLAAIM, BLAGIM, BLANDM AND BLAVIM GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN TEHRAN HOSPITALS, IRAN

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ACINETOBACTER BAUMANNIIQ2

METALLO-BETA-LACTAMASEQ3

ANTIBIOTIC RESISTANCEQ3

Abstract

Background and Aim: The rising trend of ANTIBIOTIC RESISTANCE among A. baumannii strains has become a global concern. The most common mechanism of resistance is beta-lactamase production with genes transferring on mobile genetic elements such as plasmids. The aim of this study was to determine the frequency of blaNDM, blaGIM, blaAIM, blaDIM and blaVIM type genes among A. baumannii isolates from hospitalized patients in Tehran, Iran.Materials and Methods: From May 2012 to July 2013, 108 A. baumannii strains were isolated from blood, wound, urine, sputum and respiratory tract of hospitalized patients in Loghman hakim and Milad hospitals. Antibiotic susceptibility tests were performed by Kirby-Bauer disc diffusion and broth microdilution methods according the CLSI guidelines. The frequency of MBL (Metallo-Beta-Lactamase) producers was evaluated by CDDT. The β-lactamases genes were detected by PCR method.Results: The resistance of A. baumannii isolates against tested antibiotics were as follows: 103 (95.4%) to ceftazidime, 108 (100%) to cefotaxime, 105 (95.7%) to cefepime, 99 (91.7%) to imipenem, 99 (91.7%) to meropenem, 87 (80.6%) to amikacin, 105 (97.2%) to piperacillin, 100 (92.6%) to ciprofloxacin, 103 (95.4%) to piperacillin/ tazobactam, 44 (40.7%) to gentamicin, 106 (98.1%) to ampicillin/sulbactam, 106 (98.1%) to co-trimoxazole, 87 (80.6%) to tetracycline, and 1 (0.9%) to colistin. Using combined disk diffusion test, 86 (86.86%) were MBL producers. The prevalence of blaVIM-1 gene was 15 (17.44%) and other genes were not detected.Conclusions: The prevalence of MBLs-producing A. baumannii strains detected in this study is a major concern and highlights the need for infection control measures such as antibiotic management protocols and rapid identification of resistant strains.

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APA: Copy

GOUDARZI, HOSSEIN, HASHEMI, ALI, FALLAH, FATEMEH, NOORI, MARYAM, ERFANIMANESH, SOROOR, YOUSEFI, NEDA, HEIDARY, MOHSEN, KHOSHNOOD, SAEED, & HOURI, HAMIDREZA. (2016). DETECTION OF BLADIM, BLAAIM, BLAGIM, BLANDM AND BLAVIM GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN TEHRAN HOSPITALS, IRAN. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 9(4), 32-39. SID. https://sid.ir/paper/132638/en

Vancouver: Copy

GOUDARZI HOSSEIN, HASHEMI ALI, FALLAH FATEMEH, NOORI MARYAM, ERFANIMANESH SOROOR, YOUSEFI NEDA, HEIDARY MOHSEN, KHOSHNOOD SAEED, HOURI HAMIDREZA. DETECTION OF BLADIM, BLAAIM, BLAGIM, BLANDM AND BLAVIM GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN TEHRAN HOSPITALS, IRAN. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2016;9(4):32-39. Available from: https://sid.ir/paper/132638/en

IEEE: Copy

HOSSEIN GOUDARZI, ALI HASHEMI, FATEMEH FALLAH, MARYAM NOORI, SOROOR ERFANIMANESH, NEDA YOUSEFI, MOHSEN HEIDARY, SAEED KHOSHNOOD, and HAMIDREZA HOURI, “DETECTION OF BLADIM, BLAAIM, BLAGIM, BLANDM AND BLAVIM GENES AMONG ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN TEHRAN HOSPITALS, IRAN,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 9, no. 4, pp. 32–39, 2016, [Online]. Available: https://sid.ir/paper/132638/en

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