THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON STAT-3 AND ANGIOPOIETIN-1 GENE EXPRESSION, AND TIE-2 PROTEIN IN MICE WITH BREAST CANCER

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AHMADIAN M.; AZIZBEIGI K.; DELFAN M.; ATASHAK S.

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Journal: Iranian Journal of Breast Diseases Year:2018 | Volume:11 | Issue:1 Page(s): 37-46

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Title

THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON STAT-3 AND ANGIOPOIETIN-1 GENE EXPRESSION, AND TIE-2 PROTEIN IN MICE WITH BREAST CANCER

Author(s)

AHMADIAN M. | AZIZBEIGI K. | DELFAN M. | ATASHAK S. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

HIGH INTENSITY INTERVAL TRAININGQ1

ANGIOGENESISQ1

STAT-3Q1

ANGIOPOIETIN-1 AND TIE-2Q1

Abstract

Introduction: ANGIOGENESIS has a great role in physiological development of tissues and tumors.Considering the key role of STAT-3 and angiopoietin-1-tie-2 in ANGIOGENESIS, this study aimed to investigate the effect of 10 weeks of high intensity interval exercise (HIIT) on STAT-3 and angiopoietin-1 gene expression, and tie-2 protein in mice with BREAST CANCER.Methods: After inducing cancer (subcutaneous injection of MC4-L2 on the right side of mice), twelve Balb/c mice (6-8 weeks, weight 19±1.05) were randomly assigned to HIIT (n=6) and nonactive groups (n=6). HIIT sessions were performed five days a week for 10 weeks. Twenty-four hours after the last session of HIIT, the animals were sacrificed and the tumor tissue was isolated for measuring the expression of STAT-3 and angiopoietin-1 gene by qreal time PCR and measuring tie-2 protein by western blot method. Tumor volume changes were also assessed using a digital caliper every week.Results: The results of this study showed a significant decrease in expression of STAT-3 and angiopoietin-1, and changes in tumor volume and tie-2 in the training group compared to the control group (p=0.001).Conclusion: It appears that high intensity interval exercise can reduce the rate of tumor progression through decreasing the expression of some ANGIOGENESIS promoters, and is an effective non-medical method for reducing tumor growth.

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APA: Copy

AHMADIAN, M., AZIZBEIGI, K., DELFAN, M., & ATASHAK, S.. (2018). THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON STAT-3 AND ANGIOPOIETIN-1 GENE EXPRESSION, AND TIE-2 PROTEIN IN MICE WITH BREAST CANCER. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 11(1 ), 37-46. SID. https://sid.ir/paper/144553/en

Vancouver: Copy

AHMADIAN M., AZIZBEIGI K., DELFAN M., ATASHAK S.. THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON STAT-3 AND ANGIOPOIETIN-1 GENE EXPRESSION, AND TIE-2 PROTEIN IN MICE WITH BREAST CANCER. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2018;11(1 ):37-46. Available from: https://sid.ir/paper/144553/en

IEEE: Copy

M. AHMADIAN, K. AZIZBEIGI, M. DELFAN, and S. ATASHAK, “THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON STAT-3 AND ANGIOPOIETIN-1 GENE EXPRESSION, AND TIE-2 PROTEIN IN MICE WITH BREAST CANCER,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 11, no. 1 , pp. 37–46, 2018, [Online]. Available: https://sid.ir/paper/144553/en

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