The Effect of Endurance Training in Combination with Curcumin on Intratumoral Gene Expression of AngiomiR-126 and Angiopoietin-1 in Female Mice with Breast Cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Kouchaki Langroudi F.; PEERI M.; DELFAN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS) Year:2020 | Volume:20 | Issue:3 Page(s): 410-420

Download Full-Text

Persian Verion

View:

244

Download:

Cites:

Information Journal Paper

Title

The Effect of Endurance Training in Combination with Curcumin on Intratumoral Gene Expression of AngiomiR-126 and Angiopoietin-1 in Female Mice with Breast Cancer

Author(s)

Kouchaki Langroudi F. | PEERI M. | DELFAN M. | Issue Writer Certificate

Keywords

Endurance TrainingQ1

CurcuminQ1

miR-126Q1

Angiopoitien-1Q1

Breast CancerQ2

Abstract

Background & objectives: Breast Cancer is one of the most common diseases and the leading cause of death among women worldwide. The aim of the present study was to determine the effects of five weeks of Endurance Training in combination with Curcumin on the cancer progression, intratumoral gene expression of angiomiR-126 and Angiopoietin-1 in Breast Cancer bearing female BALB/c mice. Methods: The present study was an experimental study. 4T1 Breast Cancer was transplanted into forty female BALB/c mice. Afterward, they were randomly divided into four groups including, a control group (C ), an Endurance Training group (E), an Endurance Training along with Curcumin (EC ) and Curcumin group (CC ). E and EC groups performed 40 min at a constant running intensity corresponding to 60-65% vVo2peak at 0% inclination, 5 weeks (five days a week). CC and EC groups were treated by oral gavage with Curcumin for five weeks (six days a week). Then, tumor tissue of all mice was extracted 24 hour after the last training session. Gene expression levels of miR-126 and angiopoietin-1 were determined by qRealtime PCR. Statistical data values were also measured by One-way ANOVA. Results: The results showed a significant inhibition of cancer growth, increased gene expression of miR-126 (p<0. 001) and decreased angiopoietin-1 gene expression (p<0. 001)in E, CC, and especially E-C compared to control group. All of these changes were significantly greater in the EC group than in the other intervention groups (p<0. 001). Conclusion: It seems that five weeks of Endurance Training with Curcumin supplementation possibly have a further effect on decreasing Breast Cancer mass growth by inhibiting miR-126 /angiopoietin-1 axis compared to other interventions alone.

Cites

No record.

References

Cite

APA: Copy

Kouchaki Langroudi, F., PEERI, M., & DELFAN, M.. (2020). The Effect of Endurance Training in Combination with Curcumin on Intratumoral Gene Expression of AngiomiR-126 and Angiopoietin-1 in Female Mice with Breast Cancer. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 20(3 ), 410-420. SID. https://sid.ir/paper/412522/en

Vancouver: Copy

Kouchaki Langroudi F., PEERI M., DELFAN M.. The Effect of Endurance Training in Combination with Curcumin on Intratumoral Gene Expression of AngiomiR-126 and Angiopoietin-1 in Female Mice with Breast Cancer. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2020;20(3 ):410-420. Available from: https://sid.ir/paper/412522/en

IEEE: Copy

F. Kouchaki Langroudi, M. PEERI, and M. DELFAN, “The Effect of Endurance Training in Combination with Curcumin on Intratumoral Gene Expression of AngiomiR-126 and Angiopoietin-1 in Female Mice with Breast Cancer,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 20, no. 3 , pp. 410–420, 2020, [Online]. Available: https://sid.ir/paper/412522/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops