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Title

THE EFFECTS OF AEROBIC TRAINING ON MICRORNA LET-7A EXPRESSION AND LEVELS OF TUMOR TISSUE IL-6 IN MICE WITH BREAST CANCER

Pages

  12-19

Abstract

 Background: IL-6 cytokine acts as a pro inflammatory factor in the tumor microenvironment in the BREAST CANCER. As there is a positive feedback loop between IL-6 and MICRORNA LET-7A, which is postulated to function as a tumor suppressor in most cancers, we investigated the effects of AEROBIC TRAINING on MICRORNA LET-7A expression and levels of tumor tissue IL-6 in mice with BREAST CANCER.Methods: Twenty BALB/c mice (4-5 weeks old) were injected estrogen-dependent receptor BREAST CANCER cells MC4-L2 and divided into two groups: tumor-training (TT) and tumor-control (TC) group. Then TT group performed progressive AEROBIC TRAINING for 6 weeks, 5 days per week (14-18 m/min). After tumor emersion, tumor width and length were measured by digital caliper every week.48 hours after the last exercise subjects were killed. Tissue sampling were collected and stored in -70o. Tumor tissue was homogenized and let-7a expression and IL-6 levels were accounted with Real time-PCR and ELISA Kit respectively. Statistical analysis of let-7a was conducted by the REST software. Repeated measures and independent t tests were used to assess tumor size and IL-6, respectively.Results: Tumor size and IL-6 levels were significantly decreased in TT group compared with TC group (p<0.05). MICRORNA LET-7A was increased significantly in TT group following AEROBIC TRAINING compared with TC group (p<0.05).Conclusion: Reduction in tumor size in BALB/c mice and, followed by aerobic exercise can be attributed to the loss of inflammatory factors such as IL-6 and also up regulation of MICRORNA LET-7A. These data provide strong support for a beneficial effect of exercise training on tumor progression in mouse model of BREAST CANCER that may be partly mediated by its anti-inflammatory potential.

Cites

References

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APA: Copy

ANOOSHEH, LEILA, KORDI, MOHAMMAD REZA, GAEINI, ABBASALI, MAHDIAN, REZA, MIRAKHORI, ZAHRA, AMANI SHALAMZARI, SADEGH, & AMINI, ASHRAF. (2014). THE EFFECTS OF AEROBIC TRAINING ON MICRORNA LET-7A EXPRESSION AND LEVELS OF TUMOR TISSUE IL-6 IN MICE WITH BREAST CANCER. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 7(3), 12-19. SID. https://sid.ir/paper/144606/en

Vancouver: Copy

ANOOSHEH LEILA, KORDI MOHAMMAD REZA, GAEINI ABBASALI, MAHDIAN REZA, MIRAKHORI ZAHRA, AMANI SHALAMZARI SADEGH, AMINI ASHRAF. THE EFFECTS OF AEROBIC TRAINING ON MICRORNA LET-7A EXPRESSION AND LEVELS OF TUMOR TISSUE IL-6 IN MICE WITH BREAST CANCER. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2014;7(3):12-19. Available from: https://sid.ir/paper/144606/en

IEEE: Copy

LEILA ANOOSHEH, MOHAMMAD REZA KORDI, ABBASALI GAEINI, REZA MAHDIAN, ZAHRA MIRAKHORI, SADEGH AMANI SHALAMZARI, and ASHRAF AMINI, “THE EFFECTS OF AEROBIC TRAINING ON MICRORNA LET-7A EXPRESSION AND LEVELS OF TUMOR TISSUE IL-6 IN MICE WITH BREAST CANCER,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 7, no. 3, pp. 12–19, 2014, [Online]. Available: https://sid.ir/paper/144606/en

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