The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats

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HASANI S.; HABIBIAN M.

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Journal: Feyz Medical Sciences Journal Year:2018 | Volume:22 | Issue:2 Page(s): 128-133

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Title

The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats

Author(s)

HASANI S. | HABIBIAN M. | Issue Writer Certificate

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Abstract

Background: The aging process is associated with a progressive deterioration of tissues and organs. Apoptotic cell death has been known as a possible causal factor in age-related pathologies. Therefore, this study was conducted to assess the effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of aged female rats. Materials and Methods: In this experimental study, 14 aged female Wistar rats were selected and randomly divided into two equal groups (n=7) of control and exercise. The animals performed 10 bouts of 1-min high-intensity treadmill running (20– 34 m· min– 1), separated by 2 min of rest, for 3 days a week for 8 weeks. The rats were killed 48 h after the last treatment and their brain Bax and Bcl-2 levels were evaluated by the ELISA method. Results: The results showed that an 8-week, high-intensity interval exercise decreased brain Bax levels in aged rats (P<0. 05). However, a significant increase was observed in the levels of brain Bcl-2 in the exercise group (P<0. 05). Conclusion: It seems that a high-intensity exercise may mediate part of its protective effect against aging-induced apoptosis, by increasing brain Bcl-2 and suppressing Bax levels in brain.Apoptotic,Brain,High-intensity interval training

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APA: Copy

HASANI, S., & HABIBIAN, M.. (2018). The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats. FEYZ, 22(2 ), 128-133. SID. https://sid.ir/paper/40914/en

Vancouver: Copy

HASANI S., HABIBIAN M.. The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats. FEYZ[Internet]. 2018;22(2 ):128-133. Available from: https://sid.ir/paper/40914/en

IEEE: Copy

S. HASANI, and M. HABIBIAN, “The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats,” FEYZ, vol. 22, no. 2 , pp. 128–133, 2018, [Online]. Available: https://sid.ir/paper/40914/en

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