ANALYSIS OF METHYLATION STATUS OF TUMOR SUPPRESSOR CKN2A GENE IN SPORADIC BREAST CANCER

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VALLIAN S.; NASSIRI I.; SEDAGHAT M.; FARAZMAND A.; MOKARIAN F.; ABDOLLAHI M.

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Journal: Iranian Journal of Breast Diseases Year:2009 | Volume:1 | Issue:3 (3) Page(s): 7-16

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Title

ANALYSIS OF METHYLATION STATUS OF TUMOR SUPPRESSOR CKN2A GENE IN SPORADIC BREAST CANCER

Author(s)

Keywords

BREAST CANCERQ2

METHYLATIONQ4

IRANIAN POPULATIONQ4

MSPQ4

CKN2A TUMOR SUPPRESSOR GENEQ4

REPQ4

Abstract

CKN2A is a tumor suppressor gene encoding a protein which acts in REPression of Cdk4/6, and reduction of pRb phosphorylation. CKN2A gene can be inactivated by a variety of genetic and epigenetic events, including METHYLATION. To investigate the METHYLATION status of the CKN2A gene exon 1 in Iranian patients with breast carcinoma, promoter METHYLATION was studied by METHYLATION specific PCR (MSP), and restriction enzyme-related PCR (REP). An analysis of 65 patients by MPS and RPE showed hypermethylation of CKN2A in 29% (19.78) and 35% (23.78) of specimens, respectively. The pathological history of cancerous tissue sections suggested that CKN2A gene might be inactivated at the early stages in BREAST CANCER, and that it is one of the epigenetic factors affecting the progress of the cancer.

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APA: Copy

VALLIAN, S., NASSIRI, I., SEDAGHAT, M., FARAZMAND, A., MOKARIAN, F., & ABDOLLAHI, M.. (2009). ANALYSIS OF METHYLATION STATUS OF TUMOR SUPPRESSOR CKN2A GENE IN SPORADIC BREAST CANCER. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 1(3 (3)), 7-16. SID. https://sid.ir/paper/144640/en

Vancouver: Copy

VALLIAN S., NASSIRI I., SEDAGHAT M., FARAZMAND A., MOKARIAN F., ABDOLLAHI M.. ANALYSIS OF METHYLATION STATUS OF TUMOR SUPPRESSOR CKN2A GENE IN SPORADIC BREAST CANCER. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2009;1(3 (3)):7-16. Available from: https://sid.ir/paper/144640/en

IEEE: Copy

S. VALLIAN, I. NASSIRI, M. SEDAGHAT, A. FARAZMAND, F. MOKARIAN, and M. ABDOLLAHI, “ANALYSIS OF METHYLATION STATUS OF TUMOR SUPPRESSOR CKN2A GENE IN SPORADIC BREAST CANCER,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 1, no. 3 (3), pp. 7–16, 2009, [Online]. Available: https://sid.ir/paper/144640/en

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