NFκB GENE EXPRESSION SURVEY IN PERIPHERAL BLOOD CELL OF SARDASHT WARFARE AGENT VICTIMS 20 YEARS AFTER EXPOSURE TO SULFUR MUSTARD

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PARVIZPOUR FARZAD; GHAZANFARI TOOBA; SALIMI HASSAN; FAGHIHZADEH SOGHRAT; YARAEE ROYA; SHARIFNIA ZARIN; SOROOSH MOHAMAD REZA; NAGHIZADEH MOHAMMAD MEHDI

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Journal: Iranian Journal of War and Public Health Year:2011 | Volume:3 | Issue:12 Page(s): 38-47

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Title

NFκB GENE EXPRESSION SURVEY IN PERIPHERAL BLOOD CELL OF SARDASHT WARFARE AGENT VICTIMS 20 YEARS AFTER EXPOSURE TO SULFUR MUSTARD

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Keywords

NFκBQ2

MUSTARDQ2

SARDASHTQ2

CYTOKINEQ2

INFLAMMATORYQ3

PCRQ2

Abstract

Background: Transcription factor NFkB is responsible for a large number of genes expression including INFLAMMATORY CYTOKINEs, chemokine, immune receptors, enzymes and other preinflammatory molecules. NFkB deviation is one of the mechanisms of some diseases especially those that are associated with inflammation or apoptosis. Sulfur MUSTARD is an alkylating agent that can damage enzymes, DNA and other macromolecules, also induces oxidative stress responses. Results obtained from recent studies on SARDASHT sulfur MUSTARD victims 20 years after exposure showed alterations on immune and INFLAMMATORY responses. Regard to NFkB significance in INFLAMMATORY and its related CYTOKINEs in this research we assessed NFkB level in these victims. Purpose: NFkB gene expression assess in MUSTARD victims 20 years after exposure.Methods and materials: Population study was 189 people of SARDASHT sulfur MUSTARD victims and control group include 32 people of Rabat civil. Sampling procedure was systematic random. The result analyzed by SPSS and X2 and T-test static procedures. For nonparametric analysis Mann-Witney and Kruskall-Wallis were used. NFkB expression levels were evaluated by standard PCR in peripheral white blood cells.Results: Result assessment in two groups showed that NFkB median in exposure group were 188.75 ngr/ml and in control group were 142.84 ngr/ml which NFkB expression level in exposure group was upregulated. This increasing was significant (P= 0.009).Conclusion: NFkB factor involved in many cellular functions, so its increasing or decreasing has its own results. Due to reduction of INFLAMMATORY factors in these victims, its decline was expected but the results of this study showed its increment which likely was for compensates the reduction of INFLAMMATORY factors.

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APA: Copy

PARVIZPOUR, FARZAD, GHAZANFARI, TOOBA, SALIMI, HASSAN, FAGHIHZADEH, SOGHRAT, YARAEE, ROYA, SHARIFNIA, ZARIN, SOROOSH, MOHAMAD REZA, & NAGHIZADEH, MOHAMMAD MEHDI. (2011). NFκB GENE EXPRESSION SURVEY IN PERIPHERAL BLOOD CELL OF SARDASHT WARFARE AGENT VICTIMS 20 YEARS AFTER EXPOSURE TO SULFUR MUSTARD. IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ), 3(12), 38-47. SID. https://sid.ir/paper/152358/en

Vancouver: Copy

PARVIZPOUR FARZAD, GHAZANFARI TOOBA, SALIMI HASSAN, FAGHIHZADEH SOGHRAT, YARAEE ROYA, SHARIFNIA ZARIN, SOROOSH MOHAMAD REZA, NAGHIZADEH MOHAMMAD MEHDI. NFκB GENE EXPRESSION SURVEY IN PERIPHERAL BLOOD CELL OF SARDASHT WARFARE AGENT VICTIMS 20 YEARS AFTER EXPOSURE TO SULFUR MUSTARD. IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ)[Internet]. 2011;3(12):38-47. Available from: https://sid.ir/paper/152358/en

IEEE: Copy

FARZAD PARVIZPOUR, TOOBA GHAZANFARI, HASSAN SALIMI, SOGHRAT FAGHIHZADEH, ROYA YARAEE, ZARIN SHARIFNIA, MOHAMAD REZA SOROOSH, and MOHAMMAD MEHDI NAGHIZADEH, “NFκB GENE EXPRESSION SURVEY IN PERIPHERAL BLOOD CELL OF SARDASHT WARFARE AGENT VICTIMS 20 YEARS AFTER EXPOSURE TO SULFUR MUSTARD,” IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ), vol. 3, no. 12, pp. 38–47, 2011, [Online]. Available: https://sid.ir/paper/152358/en

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