GENOMIC ANALYSIS OF C-FOS IN AIRWAY WALL OF COPD PATIENTS AT MRNA LEVEL VIA INCREASE OF REACTIVE OXYGEN SPECIES AFTER COUNTERING TO SULFUR MUSTARD

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YAZDANI SAMANEH; KARIMFAR MOHAMMAD HASSAN; IMANI FOOLADI ABASS ALI; NOURANI MOHAMMAD REZA

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Journal: Iranian Journal of War and Public Health Year:2011 | Volume:3 | Issue:10 Page(s): 46-52

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Title

GENOMIC ANALYSIS OF C-FOS IN AIRWAY WALL OF COPD PATIENTS AT MRNA LEVEL VIA INCREASE OF REACTIVE OXYGEN SPECIES AFTER COUNTERING TO SULFUR MUSTARD

Author(s)

YAZDANI SAMANEH | KARIMFAR MOHAMMAD HASSAN | IMANI FOOLADI ABASS ALI | NOURANI MOHAMMAD REZA | Issue Writer Certificate

Keywords

BRONCHIAL WALLQ3

SULFUR MUSTARDQ3

AP-1Q2

ROSQ3

C-FOSQ3

Abstract

Introduction: The airway epithelium as a physiological barrier defend airway against environmental hazards in lung disease such as Chronic Obstructive Pulmonary Disease (COPD). This defense seems to be regulated via alteration of inflammatory genes and Reactive oxygen species (ROS) have an important role in expression of inflammatory proteins. ROS promote the up regulation of cytokines and inflammatory proteins via activation of transcription factors such as Activated Protein 1 (AP-1). SULFUR MUSTARD (SM) is one of the hazardous agents which cause increase of ROS. In this study we will highlight the role of AP-1 in activation of cytokines and inflammatory molecules following the increase of ROS after exposure to SM in airway wall and for this purpose we chose C-FOS which is the most common monodimer of AP-1. Materials and Methods: Ten control individuals and twenty SM exposed patients were considered. RT-PCR and Real-time PCR measured the quantity of C-FOS mRNA in control and SM exposed specimens. Results: Although this research showed 2.89 fold changes in expression levels of C-FOS in SM exposed patients in compare to normal group, our result was not statistically remarkable (P>0.05). Discussion: Our evidence suggested that the induction of C-FOS is may be because of increase of ROS after exposure to SM and having no statistically remarkable result is might refer to depletion of antioxidants.

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APA: Copy

YAZDANI, SAMANEH, KARIMFAR, MOHAMMAD HASSAN, IMANI FOOLADI, ABASS ALI, & NOURANI, MOHAMMAD REZA. (2011). GENOMIC ANALYSIS OF C-FOS IN AIRWAY WALL OF COPD PATIENTS AT MRNA LEVEL VIA INCREASE OF REACTIVE OXYGEN SPECIES AFTER COUNTERING TO SULFUR MUSTARD. IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ), 3(10), 46-52. SID. https://sid.ir/paper/152379/en

Vancouver: Copy

YAZDANI SAMANEH, KARIMFAR MOHAMMAD HASSAN, IMANI FOOLADI ABASS ALI, NOURANI MOHAMMAD REZA. GENOMIC ANALYSIS OF C-FOS IN AIRWAY WALL OF COPD PATIENTS AT MRNA LEVEL VIA INCREASE OF REACTIVE OXYGEN SPECIES AFTER COUNTERING TO SULFUR MUSTARD. IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ)[Internet]. 2011;3(10):46-52. Available from: https://sid.ir/paper/152379/en

IEEE: Copy

SAMANEH YAZDANI, MOHAMMAD HASSAN KARIMFAR, ABASS ALI IMANI FOOLADI, and MOHAMMAD REZA NOURANI, “GENOMIC ANALYSIS OF C-FOS IN AIRWAY WALL OF COPD PATIENTS AT MRNA LEVEL VIA INCREASE OF REACTIVE OXYGEN SPECIES AFTER COUNTERING TO SULFUR MUSTARD,” IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ), vol. 3, no. 10, pp. 46–52, 2011, [Online]. Available: https://sid.ir/paper/152379/en

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