PROTECTIVE EFFECTS OF QUERCETIN ON SPERMATOGENESIS IN STREPTOZOTOCININDUCED DIABETIC RAT

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KHAKI ARASH; NOURI M.; FATHI AZAD F.; AHMADI ASHTIANI HAMID REZA; RASTGAR HOSSEIN; REZAZADEH SH.

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Journal: Journal of Medicinal Plants Year:2009 | Volume:8 | Issue:SUPPLEMENT 5 Page(s): 57-64

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Title

PROTECTIVE EFFECTS OF QUERCETIN ON SPERMATOGENESIS IN STREPTOZOTOCININDUCED DIABETIC RAT

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Keywords

QUERCETINQ4

STREPTOZOTOCINQ4

SPERMATOGENESISQ4

RATQ4

Abstract

Background: QUERCETIN is a strong antioxidant and long-term treatment of STZdiabetic animals and it has been shown to reduce oxidative stress.Objective: antioxidants have essential effect on SPERMATOGENESIS and sperm parameters. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.Methods: Wistar male RAT (n=40) were allocated into three groups, control group (n=10) and QUERCETIN (QR) group that received 15mg/kg (IP) QR, (n=10), and Diabetic group that received 55 mg/kg (IP) STREPTOZOTOCIN (STZ) (n=20) which was subdivided to two groups of 10; STZ group and treatment group. Treatment group received 55 mg/kg (IP) STZ plus15mg/kg QR, daily for,4 weeks, respectively; however, the control group just received an equal volume of distilled water daily (IP). Diabetes was induced by a single intra peritonea injection of STREPTOZOTOCIN (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for testosterone, TAC, MDA and Ox-LDL levels and testes tissues of RAT in whole groups were removed and sperm was collected from epididymis then prepared for analysis.Results: Sperm population, percentage of sperm viability and motility significantly increased in group that has received 15 mg/kg (IP) QUERCETIN (p<0.05) in comparison to control and experimental groups.Conclusion: Since in our study 15 mg/kg (IP) QUERCETIN have significantly Preventive effect on Sperm percentage of viability and motility by reducing level of Reactive Oxygen Species (ROS) in serum, so it seems that using it can be effective for sperm healthy parameters in Diabetic RAT.

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APA: Copy

KHAKI, ARASH, NOURI, M., FATHI AZAD, F., AHMADI ASHTIANI, HAMID REZA, RASTGAR, HOSSEIN, & REZAZADEH, SH.. (2009). PROTECTIVE EFFECTS OF QUERCETIN ON SPERMATOGENESIS IN STREPTOZOTOCININDUCED DIABETIC RAT. JOURNAL OF MEDICINAL PLANTS, 8(SUPPLEMENT 5), 57-64. SID. https://sid.ir/paper/15293/en

Vancouver: Copy

KHAKI ARASH, NOURI M., FATHI AZAD F., AHMADI ASHTIANI HAMID REZA, RASTGAR HOSSEIN, REZAZADEH SH.. PROTECTIVE EFFECTS OF QUERCETIN ON SPERMATOGENESIS IN STREPTOZOTOCININDUCED DIABETIC RAT. JOURNAL OF MEDICINAL PLANTS[Internet]. 2009;8(SUPPLEMENT 5):57-64. Available from: https://sid.ir/paper/15293/en

IEEE: Copy

ARASH KHAKI, M. NOURI, F. FATHI AZAD, HAMID REZA AHMADI ASHTIANI, HOSSEIN RASTGAR, and SH. REZAZADEH, “PROTECTIVE EFFECTS OF QUERCETIN ON SPERMATOGENESIS IN STREPTOZOTOCININDUCED DIABETIC RAT,” JOURNAL OF MEDICINAL PLANTS, vol. 8, no. SUPPLEMENT 5, pp. 57–64, 2009, [Online]. Available: https://sid.ir/paper/15293/en

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