THE PROTECTIVE EFFECT OF QUERCETIN AND IT NANOCRYSTAL ON ANXIETY-LIKE BEHAVIORS INDUCED BY ANIMAL MODEL OF ALZHEIMER’S DISEASE

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HAJIZADEHMOGHADDAM A.; ZARE M.; ROSTAMIAN S.; KHANJANI S.

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Journal: Journal of Medicinal Plants Year:2017 | Volume:16 | Issue:62 Page(s): 158-168

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Title

THE PROTECTIVE EFFECT OF QUERCETIN AND IT NANOCRYSTAL ON ANXIETY-LIKE BEHAVIORS INDUCED BY ANIMAL MODEL OF ALZHEIMER’S DISEASE

Author(s)

HAJIZADEHMOGHADDAM A. | ZARE M. | ROSTAMIAN S. | KHANJANI S. | Issue Writer Certificate

Keywords

ALZHEIMERQ2

ANXIETYQ2

RATQ1

STREPTOZOTOCINQ1

QUERCETIN NANOCRYSTALQ3

Abstract

Introduction: ALZHEIMER is a neurodegenerative disease which is characterized by progressive memory loss, diminished cognitive ability and behavioral disturbances such as ANXIETY-like behaviors. Quercetin is a polyphenolic compound with antioxidant and neuroprotective effects. Objective: Purpose of this study is evaluated anxiolytic effect of quercetin and its nanocrystal in model of ALZHEIMER’s disease.Methods: In this experimental study, forty-nine male RATs were randomly divided into seven groups, as follows: control group (intact RATs), vehicle (received distilled water orally and intrcerebroventricullary), disease (received 10mg/rat STZ intracerebroventricularly and distilled water orally) and disease treated groups (received quercetin and its nanocrystal at doses of 10 and 25 mg/kg/day orally for four weeks after injection of STZ). Elevated plus maze (EPM) test was used to assess ANXIETY-like behaviors.Results: Results indicated that icv-STZ injection significantly decrease percent of open arm times (%OAT) and percent of open arm enters (%OAE) in the EPM test (P<0.001) and treatment with the quercetin and its nanocrystal significantly increased these behavioral indexes in the end of third and fourth weeks (P<0.001). Furthermore, treatment with QUERCETIN NANOCRYSTAL increased %OAT and %OAE more than the quercetin.Conclusion: This study showed the protective effect of quercetin and its nanocrystal in the prevention of anxiogenic-like behaviors induced by ALZHEIMER’s model of RAT and treatment with QUERCETIN NANOCRYSTAL was more effective than quercetin.

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APA: Copy

HAJIZADEHMOGHADDAM, A., ZARE, M., ROSTAMIAN, S., & KHANJANI, S.. (2017). THE PROTECTIVE EFFECT OF QUERCETIN AND IT NANOCRYSTAL ON ANXIETY-LIKE BEHAVIORS INDUCED BY ANIMAL MODEL OF ALZHEIMER’S DISEASE. JOURNAL OF MEDICINAL PLANTS, 16(62), 158-168. SID. https://sid.ir/paper/15364/en

Vancouver: Copy

HAJIZADEHMOGHADDAM A., ZARE M., ROSTAMIAN S., KHANJANI S.. THE PROTECTIVE EFFECT OF QUERCETIN AND IT NANOCRYSTAL ON ANXIETY-LIKE BEHAVIORS INDUCED BY ANIMAL MODEL OF ALZHEIMER’S DISEASE. JOURNAL OF MEDICINAL PLANTS[Internet]. 2017;16(62):158-168. Available from: https://sid.ir/paper/15364/en

IEEE: Copy

A. HAJIZADEHMOGHADDAM, M. ZARE, S. ROSTAMIAN, and S. KHANJANI, “THE PROTECTIVE EFFECT OF QUERCETIN AND IT NANOCRYSTAL ON ANXIETY-LIKE BEHAVIORS INDUCED BY ANIMAL MODEL OF ALZHEIMER’S DISEASE,” JOURNAL OF MEDICINAL PLANTS, vol. 16, no. 62, pp. 158–168, 2017, [Online]. Available: https://sid.ir/paper/15364/en

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