THE EXPRESSION OF TISSUE MATRIX METALLOPROTEINASE 2 AND 9 IN EROSIVE AND NON-EROSIVE ORAL LICHEN PLANUS, INFLAMMATORY HYPERPLASIA OF ORAL MUCOSA BY IMMUNOHISTOCHEMISTRY

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DELAVARAN Z.; MOHTASHAM N.; JAVADZADEH BOLOURI A.; BABAKOUHI SH.; SADR BARDIA; SHAKERI M.T.; KAMYAB HESARI K.; BIDRAM F.

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Journal: Dermatology and Cosmetics Year:2010 | Volume:1 | Issue:1 Page(s): 6-13

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Title

THE EXPRESSION OF TISSUE MATRIX METALLOPROTEINASE 2 AND 9 IN EROSIVE AND NON-EROSIVE ORAL LICHEN PLANUS, INFLAMMATORY HYPERPLASIA OF ORAL MUCOSA BY IMMUNOHISTOCHEMISTRY

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Keywords

ORAL LICHEN PLANUSQ3

TISSURE INHIBITOR MATRIX METALLOPROTEINASE 2Q3

TISSUE INHIBITOR MATRIX METALLOPROTEINASE 9Q3

Abstract

Background and aim: ORAL LICHEN PLANUS, is a chronic inflammatory mucocutanous lesion which is defined as a premalignant lesion. Matrix metaloprotenase 2(MMP-2) and MMP-9 are protenases which facilitates invasion of tumoral cells to connective tissue and are over-expressed in premalignant and malignant lesions. The aim of this study was to determine the expression of MMP-2 in erosive and non-erosive ORAL LICHEN PLANUS and inflammatory hyperplasia by immunohistochemistry.Methods: in this cross sectional study 39 specimens of non-erosive ORAL LICHEN PLANUS (with and without dysplasia), 36 specimens of erosive ones (11 dysplastic and 25 non- dysplastic0, 32 inflammatory hyperplasias and 6 samples of normal oral mucosa were chosen form pathology archive of Faculty of Dentistry, Mashhad university of Medical Sciences and were stained immunohistochemically by MMP-2 and MMP-9 markers. Kruskal-Wallis, Mann-Whitney and Spearman correlation coefficient were used.Results: The highest mean expression of MMP-2 and MMP-9 (in all layers) were observed in erosive ORAL LICHEN PLANUS (68.18±31.62 and 94.5±3.5, respectively). MMP-9 expression in erosive ORAL LICHEN PLANUS in comparison to non-erosive one showed significant difference in all layers (P<0.001) and the expression of MMP-2 showed a significant difference in basal–para basal and prickle layers (respectively: P=0.008, P<0.001).Conclusion: the linear increase seen in the expression of markers from normal mucosa to erosive ORAL LICHEN PLANUS indicates the difference of biological behavior between erosive and non-erosive ORAL LICHEN PLANUS. Hence, it is concluded that erosive ORAL LICHEN PLANUS is of the higher premalignan potential compared with its non-erosive correspondent.

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APA: Copy

DELAVARAN, Z., MOHTASHAM, N., JAVADZADEH BOLOURI, A., BABAKOUHI, SH., SADR, BARDIA, SHAKERI, M.T., KAMYAB HESARI, K., & BIDRAM, F.. (2010). THE EXPRESSION OF TISSUE MATRIX METALLOPROTEINASE 2 AND 9 IN EROSIVE AND NON-EROSIVE ORAL LICHEN PLANUS, INFLAMMATORY HYPERPLASIA OF ORAL MUCOSA BY IMMUNOHISTOCHEMISTRY. DERMATOLOGY AND COSMETIC, 1(1), 6-13. SID. https://sid.ir/paper/157694/en

Vancouver: Copy

DELAVARAN Z., MOHTASHAM N., JAVADZADEH BOLOURI A., BABAKOUHI SH., SADR BARDIA, SHAKERI M.T., KAMYAB HESARI K., BIDRAM F.. THE EXPRESSION OF TISSUE MATRIX METALLOPROTEINASE 2 AND 9 IN EROSIVE AND NON-EROSIVE ORAL LICHEN PLANUS, INFLAMMATORY HYPERPLASIA OF ORAL MUCOSA BY IMMUNOHISTOCHEMISTRY. DERMATOLOGY AND COSMETIC[Internet]. 2010;1(1):6-13. Available from: https://sid.ir/paper/157694/en

IEEE: Copy

Z. DELAVARAN, N. MOHTASHAM, A. JAVADZADEH BOLOURI, SH. BABAKOUHI, BARDIA SADR, M.T. SHAKERI, K. KAMYAB HESARI, and F. BIDRAM, “THE EXPRESSION OF TISSUE MATRIX METALLOPROTEINASE 2 AND 9 IN EROSIVE AND NON-EROSIVE ORAL LICHEN PLANUS, INFLAMMATORY HYPERPLASIA OF ORAL MUCOSA BY IMMUNOHISTOCHEMISTRY,” DERMATOLOGY AND COSMETIC, vol. 1, no. 1, pp. 6–13, 2010, [Online]. Available: https://sid.ir/paper/157694/en

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