COMPARISON OF THE EFFICACY OF 0.05% TRETINOIN WITH 7% ALPHA-HYDROXY ACID CREAM IN THE TREATMENT OF EPHELIDES: A CONTROLLED CLINICAL TRIAL

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HERIZCHI QADIM HAMIDEH; BABAEI NEJAD SHAHLA; GOLFOROUSHAN FARIDEH; AZIMI HAMIDEH; AZADI AZADEH

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Journal: Dermatology and Cosmetics Year:2011 | Volume:2 | Issue:3 Page(s): 137-142

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Title

COMPARISON OF THE EFFICACY OF 0.05% TRETINOIN WITH 7% ALPHA-HYDROXY ACID CREAM IN THE TREATMENT OF EPHELIDES: A CONTROLLED CLINICAL TRIAL

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Keywords

EPHELIDSQ2

TRETINOINQ2

ALPHA-HYDROXY ACIDQ2

Abstract

Background and Aim: Anti-inflammatory and hypopigmenting effects of topical TRETINOIN and ALPHA-HYDROXY ACIDs have been documented. This study was designed to compare the efficacy of 0.05% tretinion cream with 7% alphahydroxy acid in the treatment of ephelides.Methods: In this clinical trial 80 patients with ephelides were selected and allocated into two groups. One group was treated with 0.05% TRETINOIN cream every other night. The other group was treated with 7% ALPHA-HYDROXY ACID cream in the same manner. Both groups were treated with antisolar creams and followed every month for 5 months.Results: After 5 months excellent therapeutic response was achieved in 3 (7.5%) of patients who were treated with 0.05% TRETINOIN cream compared to 8 (20%) in ALPHA-HYDROXY ACID cream. Good therapeutic response was observed in 20 (50%) of TRETINOIN group versus 16 (40%) in ALPHA-HYDROXY ACID group. Patient's satisfaction from treatment was consistent with evaluation by dermatologists (P=0.384 and P=0.132).Conclusion: Both 0.05% TRETINOIN cream and 7% alphahydroxy acid cream are equally efficient in the treatment of ephelides.

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APA: Copy

HERIZCHI QADIM, HAMIDEH, BABAEI NEJAD, SHAHLA, GOLFOROUSHAN, FARIDEH, AZIMI, HAMIDEH, & AZADI, AZADEH. (2011). COMPARISON OF THE EFFICACY OF 0.05% TRETINOIN WITH 7% ALPHA-HYDROXY ACID CREAM IN THE TREATMENT OF EPHELIDES: A CONTROLLED CLINICAL TRIAL. DERMATOLOGY AND COSMETIC, 2(3), 137-142. SID. https://sid.ir/paper/157724/en

Vancouver: Copy

HERIZCHI QADIM HAMIDEH, BABAEI NEJAD SHAHLA, GOLFOROUSHAN FARIDEH, AZIMI HAMIDEH, AZADI AZADEH. COMPARISON OF THE EFFICACY OF 0.05% TRETINOIN WITH 7% ALPHA-HYDROXY ACID CREAM IN THE TREATMENT OF EPHELIDES: A CONTROLLED CLINICAL TRIAL. DERMATOLOGY AND COSMETIC[Internet]. 2011;2(3):137-142. Available from: https://sid.ir/paper/157724/en

IEEE: Copy

HAMIDEH HERIZCHI QADIM, SHAHLA BABAEI NEJAD, FARIDEH GOLFOROUSHAN, HAMIDEH AZIMI, and AZADEH AZADI, “COMPARISON OF THE EFFICACY OF 0.05% TRETINOIN WITH 7% ALPHA-HYDROXY ACID CREAM IN THE TREATMENT OF EPHELIDES: A CONTROLLED CLINICAL TRIAL,” DERMATOLOGY AND COSMETIC, vol. 2, no. 3, pp. 137–142, 2011, [Online]. Available: https://sid.ir/paper/157724/en

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