Protective effect of Henna (Lawsonia inermis L. ) fixed oil (a Persian medicine preparation) on acetic acid-induced ulcerative colitis in rats

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Zareshahi Raheleh; Jahanabadi Samane; Rafiyan Sadaf; Yadegary Maryam; Edalatkhah Roohollah; mahmoodian hamed

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: AVICENNA JOURNAL OF PHYTOMEDICINE Year:2025 | Volume:15 | Issue:4 Page(s): 1241-1251

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Title

Protective effect of Henna (Lawsonia inermis L. ) fixed oil (a Persian medicine preparation) on acetic acid-induced ulcerative colitis in rats

Author(s)

Keywords

Ulcerative colitis

Lawsonia inermis

Fixed oil

Inflammation

Rat

Abstract

Objective: rative colitis/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Ulcerative colitis is a chronic recurrent inflammatory bowel disease of unknown etiology. The anti-inflammatory, immunomodulatory, and antioxidant characteristics of Henna (Lawsonia inermis) fixed oil (HFO) imply that it may be advantageous for the treatment of colitis. Materials and Methods: In this research, the effect of HFO in a Wistar albino rat model of acetic acid (AA)-induced rative colitis/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ulcerative colitis, was examined. The animals received daily oral administration of either normal saline (10 ml/kg), HFO (100, 400, and 1600 µl/kg), or dexamethasone (2 mg/kg) for 5 days. A single intracolonic injection of 2 ml of a 4% (v/v) acetic acid solution was used to induce colitis. The levels of myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-α) were measured. Results: The administration of HFO at doses 400 and 1600 μl/kg showed a significant enhancement in the weight-to-length ratio of colon tissue in comparison to the control group. Furthermore, the increased amounts of HFO (400 and 1600 μl/kg) were associated with a significant reduction in ulcer severity, area, and index. However, examination of tissue samples revealed a decrease in the overall colitis index suggesting fewer inflammatory cells invaded the colonic regions of rats treated with HFO at doses of 400 and 1600 μl/kg. Moreover, the elevated MPO levels and TNF-α were significantly decreased following the administration of the fixed oil at these doses. Conclusion: These findings indicate that HFO could potentially decrease the manifestations of experimental colitis in a dose-dependent manner.

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