THE ESTABLISHMENT OF IRANIAN DNA BANK FOR GENETIC AND EPIGENETIC STUDIES IN PSYCHIATRIC DISORDERS

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GHADIRI MOHAMMAD; NOHESARA SHABNAM; MOSTAFAVI ABDOLMALEKY HAMID; AHMADKHANIHA HAMID REZA; TABAN MOZHGAN

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Journal: Iranian Journal of Psychiatry and Clinical Psychology Year:2012 | Volume:17 | Issue:4 (67) Page(s): 324-331

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Title

THE ESTABLISHMENT OF IRANIAN DNA BANK FOR GENETIC AND EPIGENETIC STUDIES IN PSYCHIATRIC DISORDERS

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Keywords

GENETIC BANKQ2

EPIGENETICQ2

PSYCHIATRIC DISORDERSQ2

Abstract

Objectives: In most advanced countries, there are tissue, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) banks which have been made to provide samples for researchers in order to speed up genetic studies in different medical disorders. This may save time and materials in comparison to self-governing projects that usually spend months to collect samples independently. In these banks patients are cautiously diagnosed based on international diagnostic criteria. Thus, the results are more reliable than scattered studies and meta-analysis can be done with the data generated in different laboratories using the same samples.Method: For the establishment of a DNA bank for PSYCHIATRIC DISORDERS in Iran, after clarifying the aims and signing the consent forms, 300 saliva samples were collected using Oragene DNA Kit from the patients diagnosed based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Related data to demographics, family history, date of disorder onset, duration of disorder, drugs in use and other variables were compiled and opportunity for future contacts was set to gather more information including the course of disorders.Results: A saliva bank for DNA extraction of 300 psychiatric patients suffering from schizophrenia, bipolar disorder, major depressive disorder, obsessive-compulsive disorder and attention deficit hyperactivity disorder, 30 ones relatives as well as 75 matched healthy control subjects for genetic and EPIGENETIC studies was established.Conclusion: The opportunity for donation of DNA samples collected from Iranian psychiatric patients has been provided to be used in hundreds of national and international genetic studies.

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APA: Copy

GHADIRI, MOHAMMAD, NOHESARA, SHABNAM, MOSTAFAVI ABDOLMALEKY, HAMID, AHMADKHANIHA, HAMID REZA, & TABAN, MOZHGAN. (2012). THE ESTABLISHMENT OF IRANIAN DNA BANK FOR GENETIC AND EPIGENETIC STUDIES IN PSYCHIATRIC DISORDERS. IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY, 17(4 (67)), 324-331. SID. https://sid.ir/paper/16603/en

Vancouver: Copy

GHADIRI MOHAMMAD, NOHESARA SHABNAM, MOSTAFAVI ABDOLMALEKY HAMID, AHMADKHANIHA HAMID REZA, TABAN MOZHGAN. THE ESTABLISHMENT OF IRANIAN DNA BANK FOR GENETIC AND EPIGENETIC STUDIES IN PSYCHIATRIC DISORDERS. IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY[Internet]. 2012;17(4 (67)):324-331. Available from: https://sid.ir/paper/16603/en

IEEE: Copy

MOHAMMAD GHADIRI, SHABNAM NOHESARA, HAMID MOSTAFAVI ABDOLMALEKY, HAMID REZA AHMADKHANIHA, and MOZHGAN TABAN, “THE ESTABLISHMENT OF IRANIAN DNA BANK FOR GENETIC AND EPIGENETIC STUDIES IN PSYCHIATRIC DISORDERS,” IRANIAN JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY, vol. 17, no. 4 (67), pp. 324–331, 2012, [Online]. Available: https://sid.ir/paper/16603/en

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