COMPARISON OF THE EFFECT OF VERAPAMIL, NIFEDIPINE AND DILTIAZEM ON PENTYLENETETRAZOLE-INDUCED CLONIC SEIZURE THRESHOLD IN MICE

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KHAYAT NOURI M.H.

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Journal: Avicenna Journal of Clinical Medicine Year:2007 | Volume:14 | Issue:2 (SN 44) Page(s): 28-34

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Title

COMPARISON OF THE EFFECT OF VERAPAMIL, NIFEDIPINE AND DILTIAZEM ON PENTYLENETETRAZOLE-INDUCED CLONIC SEIZURE THRESHOLD IN MICE

Author(s)

KHAYAT NOURI M.H. | Issue Writer Certificate

Keywords

DILTIAZEMQ3

NIFEDIPINEQ3

PENTYLENETETRAZOLEQ3

SEIZUREQ3

VERAPAMILQ3

Abstract

Background & Objective: VERAPAMIL, NIFEDIPINE and DILTIAZEM are calcium channel blockers widely used as a variety of cardiovascular ailment in humans. A number of studies have shown that calcium channel blockers have anticonvulsant effect in a range of animal SEIZURE models (but not all animals). The aim of this study was to investigate the effects of VERAPAMIL, NIFEDIPINE and DILTIAZEM on PENTYLENETETRAZOLE-induced SEIZURE threshold and to compare these effects in mice.Materials & Methods: In this experimental study, mice were pretreated intraperitoneally with vehicle or calcium channel blockers (0.5, 1, 2.5, 5, 10 and 20 mg/kg) before intravenously the determination of the PENTYLENETETRAZOLE-induced SEIZURE threshold.Results: Our results showed that the PENTYLENETETRAZOLE-induced SEIZURE threshold was 33.4±0.42 mg/kg in control group. In animals pretreated with VERAPAMIL, NIFEDIPINE and DILTIAZEM the PENTYLENETETRAZOLE-induced SEIZURE threshold dose dependently increased.Compare between calcium channel blockers showed that DILTIAZEM and VERAPAMIL had greatest and least effects, respectively.Conclusion: Our results suggest that the Ca2+ channel blockers possess anticonvulsant activity probably via an antagonism effect on voltage-gated Ca2+channels.

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References

THE STUDY OF LINDANE EFFECT ON PENTYLENETERTRAZOLE INDUCED CLONIZURE THRESHOLD IN MICE

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APA: Copy

KHAYAT NOURI, M.H.. (2007). COMPARISON OF THE EFFECT OF VERAPAMIL, NIFEDIPINE AND DILTIAZEM ON PENTYLENETETRAZOLE-INDUCED CLONIC SEIZURE THRESHOLD IN MICE. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 14(2 (SN 44)), 28-34. SID. https://sid.ir/paper/17244/en

Vancouver: Copy

KHAYAT NOURI M.H.. COMPARISON OF THE EFFECT OF VERAPAMIL, NIFEDIPINE AND DILTIAZEM ON PENTYLENETETRAZOLE-INDUCED CLONIC SEIZURE THRESHOLD IN MICE. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2007;14(2 (SN 44)):28-34. Available from: https://sid.ir/paper/17244/en

IEEE: Copy

M.H. KHAYAT NOURI, “COMPARISON OF THE EFFECT OF VERAPAMIL, NIFEDIPINE AND DILTIAZEM ON PENTYLENETETRAZOLE-INDUCED CLONIC SEIZURE THRESHOLD IN MICE,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 14, no. 2 (SN 44), pp. 28–34, 2007, [Online]. Available: https://sid.ir/paper/17244/en

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