THE EFFECT OF INTRAHIPPOCAMPAL INJECTION OF VERAPAMIL ON PENTYLENETETRAZOL KINDLING IN RATS

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PALIZVAN M.R.; AMINI KOMIJANI A.; GHAZNAVIRAD E.A.

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2005 | Volume:8 | Issue:3 (32) Page(s): 8-15

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Title

THE EFFECT OF INTRAHIPPOCAMPAL INJECTION OF VERAPAMIL ON PENTYLENETETRAZOL KINDLING IN RATS

Author(s)

PALIZVAN M.R. | AMINI KOMIJANI A. | GHAZNAVIRAD E.A. | Issue Writer Certificate

Keywords

PENTYLENETETRAZOLQ3

KINDLINGQ3

VERAPAMILQ4

HIPPOCAMPUSQ2

Abstract

Introduction: Studies showed that following spontaneous epilepsy in rats, the permeability of CA1 region of Hypocampus to calcium is increased. In this study the role of voltage dependent calcium channels on the development of KINDLING induced by PENTYLENETETRAZOL (PTZ) was investigated in rats.Materials and Methods: In this experimental study rats were divided into two groups. In the test group, VERAPAMIL (calcium channel blocker) was injected in the HIPPOCAMPUS (4 mg/4 min). After 20 minutes KINDLING was established by PTZ in subconvulsive dose (37.5 mg/kg ip). Convulsing activities were monitored for 20 min. The control group was the same age and undergone the same procedure exept for the injection, in which ACSF was injected without VERAPAMIL.Results: VERAPAMIL significantly (p<0.01) reduced the number of needed stimulations to progress from stage 0 to 5 of the convulsion and also significantly (p<0.05) prolonged the fifth stage of seizure.Conclusion: The results of this study suggested that interahippcampal injection of VERAPAMIL facilitated the PENTYLENETETRAZOL KINDLING in rats but had inhibitory effects on kindled animals.

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APA: Copy

PALIZVAN, M.R., AMINI KOMIJANI, A., & GHAZNAVIRAD, E.A.. (2005). THE EFFECT OF INTRAHIPPOCAMPAL INJECTION OF VERAPAMIL ON PENTYLENETETRAZOL KINDLING IN RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 8(3 (32)), 8-15. SID. https://sid.ir/paper/69725/en

Vancouver: Copy

PALIZVAN M.R., AMINI KOMIJANI A., GHAZNAVIRAD E.A.. THE EFFECT OF INTRAHIPPOCAMPAL INJECTION OF VERAPAMIL ON PENTYLENETETRAZOL KINDLING IN RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2005;8(3 (32)):8-15. Available from: https://sid.ir/paper/69725/en

IEEE: Copy

M.R. PALIZVAN, A. AMINI KOMIJANI, and E.A. GHAZNAVIRAD, “THE EFFECT OF INTRAHIPPOCAMPAL INJECTION OF VERAPAMIL ON PENTYLENETETRAZOL KINDLING IN RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 8, no. 3 (32), pp. 8–15, 2005, [Online]. Available: https://sid.ir/paper/69725/en

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