TREATMENT OF STREPTOZOTOCIN INDUCED DIABETIC MALE RATS BY IMMUNOISOLATED TRANSPLANTATION OF ISLET CELLS

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AKBARZADEH AZIM; JAMSHIDI SHIRIN; FARAHMAND B.; LAMERAD B.; MOFIDIAN S.M.A.

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Journal: Avicenna Journal of Clinical Medicine Year:2005 | Volume:12 | Issue:3 (SN 37) Page(s): 29-35

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Title

TREATMENT OF STREPTOZOTOCIN INDUCED DIABETIC MALE RATS BY IMMUNOISOLATED TRANSPLANTATION OF ISLET CELLS

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Keywords

DIABETES MELLITUSQ3

IMMUNOISOLATIONQ3

ISLET CELLSQ3

TRANSPLANTATIONQ3

Abstract

Introduction & Objective: Insulin injection is the main way to combat against insulin dependent DIABETES MELLITUS effects. Today in some laboratories in the world, the investigators are trying to find some treatments for this disease with insulin-secreting pancreatic ISLET CELLS TRANSPLANTATION. Encapsulation of pancreatic ISLET CELLS allows for TRANSPLANTATION in the absence of immunosuppressant. This technique that is called IMMUNOISOLATION is based on the principle that transplanted tissue is protected for the host immune system by an artificial or natural membrane.Materials & Methods: Donor tissues in each step of work prepared from 6 adult male Wistar Rat with weight 250-300 grams (75-90 days). TRANSPLANTATION was done in rats after 2-4 week induced diabetes with 60mg/ml streptozotocin injection via intravenous.Results: he data obtained from this study showed that ISLET CELLS can be enclosed in a semi permeable membrane that permits oxygen and nutrients to reach the islets, allowing insulin to be released into the blood stream and at the same time excluding potentially destructive immune cells and antibodies.Conclusion: Testis subcutaneous and intrapretonea implantation of pure ISLET CELLS graft, that is a natural IMMUNOISOLATION method, rapidly and permanently normalized the diabetic state of streptozocin-administered animals.

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APA: Copy

AKBARZADEH, AZIM, JAMSHIDI, SHIRIN, FARAHMAND, B., LAMERAD, B., & MOFIDIAN, S.M.A.. (2005). TREATMENT OF STREPTOZOTOCIN INDUCED DIABETIC MALE RATS BY IMMUNOISOLATED TRANSPLANTATION OF ISLET CELLS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 12(3 (SN 37)), 29-35. SID. https://sid.ir/paper/17285/en

Vancouver: Copy

AKBARZADEH AZIM, JAMSHIDI SHIRIN, FARAHMAND B., LAMERAD B., MOFIDIAN S.M.A.. TREATMENT OF STREPTOZOTOCIN INDUCED DIABETIC MALE RATS BY IMMUNOISOLATED TRANSPLANTATION OF ISLET CELLS. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2005;12(3 (SN 37)):29-35. Available from: https://sid.ir/paper/17285/en

IEEE: Copy

AZIM AKBARZADEH, SHIRIN JAMSHIDI, B. FARAHMAND, B. LAMERAD, and S.M.A. MOFIDIAN, “TREATMENT OF STREPTOZOTOCIN INDUCED DIABETIC MALE RATS BY IMMUNOISOLATED TRANSPLANTATION OF ISLET CELLS,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 12, no. 3 (SN 37), pp. 29–35, 2005, [Online]. Available: https://sid.ir/paper/17285/en

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