EFFECT OF ANTIOXIDANTS SUPPLEMENTATION OR RESTRICTED DIET ON OXIDATIVE STRESS IN A RAT MODEL OF DIET-INDUCED OBESITY

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VAHIDINIA A.A.; SHAKERHOSSEINI R.; MAHJUB H.

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Journal: Avicenna Journal of Clinical Medicine Year:2011 | Volume:18 | Issue:1 (SN 59) Page(s): 48-56

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Title

EFFECT OF ANTIOXIDANTS SUPPLEMENTATION OR RESTRICTED DIET ON OXIDATIVE STRESS IN A RAT MODEL OF DIET-INDUCED OBESITY

Author(s)

VAHIDINIA A.A. | SHAKERHOSSEINI R. | MAHJUB H. | Issue Writer Certificate

Keywords

ANTIOXIDANTSQ3

DIETQ2

FAT-FREEQ2

OBESITYQ2

STRESSQ2

OXIDATIVEQ2

Abstract

Introduction & Objective: OBESITY is independently associated with increased OXIDATIVE STRESS in men and women. Natural ANTIOXIDANTS showed substantial ant OXIDATIVE and anti-inflammatory activities in vivo. The aim of this study was to examine the preventive effect of antioxidant supplements and/or restricted DIET on the STRESS OXIDATIVE index (8-Iso-PGF2α) and total antioxidant capacity (TAC) in obese rats induced by a high-fat (HF) DIET.Material and Methods: In this experimental study forty-eight male Wister rats were randomly assigned to HF purified DIET (61% kcal from fat) ad libitum, HF restricted (30%), HF supplemented with astaxanthin, vitamin E and C (HFS), HFS restricted (30%) for 12 weeks. Their daily food intake and weekly body weight gain were measured. Serum 8-Iso-PGF2α and TAC measured by EIA methods.Results: Energy intake was not significant in HF with HFS (58.8 and 58.6 kcal/rat/d, respectively) and in HF restricted with HFS restricted (41.7 and 41.6 kcal/rat/d, respectively).Serum 8-Iso-PGF2α in HF was 1416.2±443.5 and in HF restricted was 1209.4±424.4pg/ml (p>0.05) and equal for other groups. The lowest TAC was seen in HF and highest was in HFS (0.36±0.43 and 3.0±1.13 mM, respectively) (p<0.001).Conclusions: These results suggest that antioxidant supplements and caloric restriction may improved TAC and partially suppress STRESS OXIDATIVE index in high fat DIET induced obese rats.

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APA: Copy

VAHIDINIA, A.A., SHAKERHOSSEINI, R., & MAHJUB, H.. (2011). EFFECT OF ANTIOXIDANTS SUPPLEMENTATION OR RESTRICTED DIET ON OXIDATIVE STRESS IN A RAT MODEL OF DIET-INDUCED OBESITY. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 18(1 (SN 59)), 48-56. SID. https://sid.ir/paper/17464/en

Vancouver: Copy

VAHIDINIA A.A., SHAKERHOSSEINI R., MAHJUB H.. EFFECT OF ANTIOXIDANTS SUPPLEMENTATION OR RESTRICTED DIET ON OXIDATIVE STRESS IN A RAT MODEL OF DIET-INDUCED OBESITY. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2011;18(1 (SN 59)):48-56. Available from: https://sid.ir/paper/17464/en

IEEE: Copy

A.A. VAHIDINIA, R. SHAKERHOSSEINI, and H. MAHJUB, “EFFECT OF ANTIOXIDANTS SUPPLEMENTATION OR RESTRICTED DIET ON OXIDATIVE STRESS IN A RAT MODEL OF DIET-INDUCED OBESITY,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 18, no. 1 (SN 59), pp. 48–56, 2011, [Online]. Available: https://sid.ir/paper/17464/en

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