MODULATED EFFECT OF DORSAL HIPPOCAMPUS (CA1) ANTAGONIST OF 5HT4 UPON ACPA INDUCED AMNESIA IN MICE

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FARRAHIZADEH M.; ZARRINDAST M.R.; NASEHI M.; BANANEJ M.

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2015 | Volume:7 | Issue:2 Page(s): 49-62

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Title

MODULATED EFFECT OF DORSAL HIPPOCAMPUS (CA1) ANTAGONIST OF 5HT4 UPON ACPA INDUCED AMNESIA IN MICE

Author(s)

FARRAHIZADEH M. | ZARRINDAST M.R. | NASEHI M. | BANANEJ M. | Issue Writer Certificate

Keywords

CANNABINOISQ2

DORSAL HIPPOCAMPUSQ2

RS23597-190Q2

SEROTONERGIC SYSTEMQ2

FEAR CONDITIONINGQ2

Abstract

The aim of present study is investigates the effects of bilateral injection of dorsal hippocampal (CA1) SEROTONERGIC SYSTEM (Antagonist of 5-HT4) in fear memory formation process induced by ACPA (Arachidonylcyclopropylamide). Male NMRI mice were used in our experiments. FEAR CONDITIONING task was used for conditioning of fear. 24 hours after train we estimated the fear memory formation. The data show that intra peritoneal administration of ACPA (0.005, 0.05 and 0.5 mg/kg) causes impairment of fear memory and amnesia. Moreover, intra-CA1 injection of 5-HT4 receptor antagonist, (RS23597-190) (0.01, 0.1 and 0.2 mg/mice) had no effect on fear memory in saline-treated mice but restored the impairment of fear memory in ACPA-treated mice. The data strongly showed that SEROTONERGIC SYSTEM (Antagonist) in the CA1 of hippocampus induced by ACPA interferes in impairment of fear memory.

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APA: Copy

FARRAHIZADEH, M., ZARRINDAST, M.R., NASEHI, M., & BANANEJ, M.. (2015). MODULATED EFFECT OF DORSAL HIPPOCAMPUS (CA1) ANTAGONIST OF 5HT4 UPON ACPA INDUCED AMNESIA IN MICE. JOURNAL OF ANIMAL BIOLOGY, 7(2), 49-62. SID. https://sid.ir/paper/177002/en

Vancouver: Copy

FARRAHIZADEH M., ZARRINDAST M.R., NASEHI M., BANANEJ M.. MODULATED EFFECT OF DORSAL HIPPOCAMPUS (CA1) ANTAGONIST OF 5HT4 UPON ACPA INDUCED AMNESIA IN MICE. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2015;7(2):49-62. Available from: https://sid.ir/paper/177002/en

IEEE: Copy

M. FARRAHIZADEH, M.R. ZARRINDAST, M. NASEHI, and M. BANANEJ, “MODULATED EFFECT OF DORSAL HIPPOCAMPUS (CA1) ANTAGONIST OF 5HT4 UPON ACPA INDUCED AMNESIA IN MICE,” JOURNAL OF ANIMAL BIOLOGY, vol. 7, no. 2, pp. 49–62, 2015, [Online]. Available: https://sid.ir/paper/177002/en

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