THE EFFECT OF DORSAL HIPPOCAMPAL α2-ADRENEGIC RECEPTORS ON WIN55,212-2 STATE-DEPENDENT MEMORY OF PASSIVE AVOIDANCE

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PIRI MORTEZA; MOSHFEGH A.; ORYAN SHAHRBANOU; ZARINDAST M.R.

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2010 | Volume:4 | Issue:3 Page(s): 29-36

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Title

THE EFFECT OF DORSAL HIPPOCAMPAL α2-ADRENEGIC RECEPTORS ON WIN55,212-2 STATE-DEPENDENT MEMORY OF PASSIVE AVOIDANCE

Author(s)

PIRI MORTEZA | MOSHFEGH A. | ORYAN SHAHRBANOU | ZARINDAST M.R. | Issue Writer Certificate

Keywords

WIN55Q3

212-2Q3

CLONIDINE; YOHIMBINEQ3

α2-ADRENEGIC RECEPTORSQ3

DORSAL HIPPOCAMPUSQ2

LEARNINGQ2

Abstract

Background and Objectives: Cannabinoids are a class of psychoactive compounds that produce a wide array of effects in a large number of species. In the present study, the effects of bilateral intra-CA1 injections of an a2-adrenergic receptor agents, on WIN55,212-2 state-dependent LEARNING were examined in adult male Wistar rats.Methods: The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the DORSAL HIPPOCAMPUS, trained in a step-down type inhibitory avoidance task, and tested 24h after training to measure step-down latency.Results: Post-training intra-CA1 injection of WIN55,212-2 (0.25 and 0.5mg/rat) induced impairment of memory retention. Amnesia produced by post-training WIN55,212-2 (0.5mg/rat) was reversed by pre-test administration of the same dose of WIN55,212-2 that is due to a state-dependent effect. Pre-test intra-CA1 injection of clonidine (0.5 and 0.75mg/rat, intra-CA1) improved post-training WIN55,212-2 (0.5mg/rat, intra-CA1)-induced retrieval impairment, while pre-test intra-CA1 injection of yohimbine (1mg/rat, intra-CA1) 2min before the administration of WIN55,212-2 (0.5mg/rat, intra-CA1) inhibited WIN55,212-2 state-dependent memory.Conclusion: These results suggest that a2-adrenergic receptors of the dorsal hippocampal CA1 regions may play an important role in WIN55,212-2-induced amnesia and WIN55,212-2 state-dependent memory.

Cites

INFLUENCE OF ETHANOL ON AMNESIA AND STATE-DEPENDENT LEARNING INDUCED BY SCOPOLAMINE IN MALE MOUSE

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APA: Copy

PIRI, MORTEZA, MOSHFEGH, A., ORYAN, SHAHRBANOU, & ZARINDAST, M.R.. (2010). THE EFFECT OF DORSAL HIPPOCAMPAL α2-ADRENEGIC RECEPTORS ON WIN55,212-2 STATE-DEPENDENT MEMORY OF PASSIVE AVOIDANCE. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 4(3), 29-36. SID. https://sid.ir/paper/132514/en

Vancouver: Copy

PIRI MORTEZA, MOSHFEGH A., ORYAN SHAHRBANOU, ZARINDAST M.R.. THE EFFECT OF DORSAL HIPPOCAMPAL α2-ADRENEGIC RECEPTORS ON WIN55,212-2 STATE-DEPENDENT MEMORY OF PASSIVE AVOIDANCE. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2010;4(3):29-36. Available from: https://sid.ir/paper/132514/en

IEEE: Copy

MORTEZA PIRI, A. MOSHFEGH, SHAHRBANOU ORYAN, and M.R. ZARINDAST, “THE EFFECT OF DORSAL HIPPOCAMPAL α2-ADRENEGIC RECEPTORS ON WIN55,212-2 STATE-DEPENDENT MEMORY OF PASSIVE AVOIDANCE,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 4, no. 3, pp. 29–36, 2010, [Online]. Available: https://sid.ir/paper/132514/en

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