The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice

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Asadi Motlagh M.; PAKPOUR B.; Navaian M.

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Journal: Feyz Medical Sciences Journal Year:2018 | Volume:22 | Issue:3 Page(s): 239-247

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Title

The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice

Author(s)

Asadi Motlagh M. | PAKPOUR B. | Navaian M. | Issue Writer Certificate

Keywords

5-HT3Q1

EthanolQ2

Passive avoidance memoryQ1

HippocapusQ2

MiceQ1

Abstract

Background: The aim of this study was to investigate the effect of 5-HT3 receptor agonist in the CA1 hippocampus area on demolition of Ethanol-induced memory. Materials and Methods: This study was conducted on 96 NMRI Mice. Ethanol was injected intraperitoneally, while 5-HT3 receptor agonist (MCHL) was injected intra-CA1. To assess the memory, a single-trial step-down passive avoidance apparatus was used. Results: Results showed that pre-training injection of Ethanol (1mg/kg), and MCHL (0. 5 ng/mouse) decreased a Passive avoidance memory in the adult Mice. Also, a non-effective dose of MCHL (0. 005 ng/mouse) with a non-effective dose of Ethanol (0. 01mg/kg) induced amnesia. Also, the results showed that injection of different doses of MCHL (0. 5, 0. 05, and 0. 005 ng/mouse) combined with an effective dose of Ethanol (1mg/kg) could retrieve damaged memory by Ethanol. Conclusion: Findings of this study showed that the CA1 region of the hippocampus has an important role in amnesia induced by serotonin and serotonin CA1 5-HT3 receptor agonists have interaction with Ethanol.

Cites

Effects of Nano-Chitosan Loaded with Donepezil on Ethanol Induced Amnesia in Swiss-type Mice

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APA: Copy

Asadi Motlagh, M., PAKPOUR, B., & Navaian, M.. (2018). The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice. FEYZ, 22(3 ), 239-247. SID. https://sid.ir/paper/40611/en

Vancouver: Copy

Asadi Motlagh M., PAKPOUR B., Navaian M.. The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice. FEYZ[Internet]. 2018;22(3 ):239-247. Available from: https://sid.ir/paper/40611/en

IEEE: Copy

M. Asadi Motlagh, B. PAKPOUR, and M. Navaian, “The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice,” FEYZ, vol. 22, no. 3 , pp. 239–247, 2018, [Online]. Available: https://sid.ir/paper/40611/en

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