MODULATED EFFECT OF 5-HT4 AGONIST UPON FEAR MEMORY IN DORSAL HIPPOCAMPUS (CA1) IN MICE

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FARAHIZADEH M.; ZARINDAST M.; NASEHI M.; BANANEJ M.

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Journal: Journal of Ilam University of Medical Sciences Year:2014 | Volume:22 | Issue:5 Page(s): 138-149

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Title

MODULATED EFFECT OF 5-HT4 AGONIST UPON FEAR MEMORY IN DORSAL HIPPOCAMPUS (CA1) IN MICE

Author(s)

FARAHIZADEH M. | ZARINDAST M. | NASEHI M. | BANANEJ M. | Issue Writer Certificate

Keywords

CANNABINERGIC SYSTEMQ2

DORSAL HIPPOCAMPUSQ2

RS67333Q2

SEROTONERGIC SYSTEMQ2

FEAR CONDITIONING TASKQ2

Abstract

Introduction: RS67333 is the selective agonist of 5-HT4 and ACPA (Arachidonylcyclopropylamide) is the selective agonist of CB1. The aim of present study was investigate the bilateral injection effects of DORSAL HIPPOCAMPUS (CA1) SEROTONERGIC SYSTEM (Agonist of 5-HT4) on fear memory formation process induced by ACPA in mature male mice.Materials & Methods: 120 Male NMRI mice weighting 23-28 gr were put into control and experimental groups in our experiments. FEAR CONDITIONING TASK was used for conditioning of fear. 24 hours after training, we estimated the fear memory formation.Findings: Intraperitoneal administration of ACPA (0.005, 0.05and 0.5 mg/kg) causes impairment of fear memory and amnesia. Moreover, intra-CA1 injection of 5-HT4 receptor agonist (RS67333) (0.005, 0.05and 0.5 mg/mice) in highest dose impaired fear memory and induced amnesia in saline-treated mice, and increased the impairment of fear memory in ACPA-treated mice (P<0.05).Discussion & Conclusion: SEROTONERGIC SYSTEM (Agonist of 5-HT4) in the CA1 of hippocampus induced by ACPA interferes in the impairment of fear memory.

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APA: Copy

FARAHIZADEH, M., ZARINDAST, M., NASEHI, M., & BANANEJ, M.. (2014). MODULATED EFFECT OF 5-HT4 AGONIST UPON FEAR MEMORY IN DORSAL HIPPOCAMPUS (CA1) IN MICE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 22(5), 138-149. SID. https://sid.ir/paper/90101/en

Vancouver: Copy

FARAHIZADEH M., ZARINDAST M., NASEHI M., BANANEJ M.. MODULATED EFFECT OF 5-HT4 AGONIST UPON FEAR MEMORY IN DORSAL HIPPOCAMPUS (CA1) IN MICE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(5):138-149. Available from: https://sid.ir/paper/90101/en

IEEE: Copy

M. FARAHIZADEH, M. ZARINDAST, M. NASEHI, and M. BANANEJ, “MODULATED EFFECT OF 5-HT4 AGONIST UPON FEAR MEMORY IN DORSAL HIPPOCAMPUS (CA1) IN MICE,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 5, pp. 138–149, 2014, [Online]. Available: https://sid.ir/paper/90101/en

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