THE EVALUATION OF EVOLUTIONAL ESTRADIOL-INDIUCED DISORDERS ON MOTOR LIMBS OF RAT'S FETUSES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NIKRAVESH M.R.; BEHNAM RASOULI MORTEZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Clinical Medicine Year:2001 | Volume:7 | Issue:4 (SN 18) Page(s): 29-34

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

763

Download:

Cites:

Information Journal Paper

Title

THE EVALUATION OF EVOLUTIONAL ESTRADIOL-INDIUCED DISORDERS ON MOTOR LIMBS OF RAT'S FETUSES

Author(s)

NIKRAVESH M.R. | BEHNAM RASOULI MORTEZA | Issue Writer Certificate

Keywords

ESTRADIOLQ2

MOTOR LIMBS- ABNORMALITIESQ4

RATSQ3

Abstract

Estrogen and progesterone is the most important female sexual hormones which is administrated for the treatment of some women diseases and also are used in contraceptive pills. Administration of female sexual hormones during critical pC-7riodof embryonic development may produce malformations. In this study which was undertaken during 1998-99 in biology department, school of sciences, Ferdowsi university of Mashhad.The incidence of motor limbs abnormality due to ESTRADIOL administration during the rat embryonic development was investigated. Three groups of pregnant wistar RATS were exposed to 0.15 mg/kg ESTRADIOL valerate via a single intramuscular injection on one of the following gestational days; 12, 14 or 16 of experimental groups 1, 2 and 3 respectively. The control pregnant RATS (group 4), were received physiological serum in the same manner. All of pregnant RATS were sacrificed on the last day of pregnancy and their fetuses were collected, counted and examined for limbs abnormalities.Our results indicate that in comparison with control group, in experimental groups the size of litters significantly reduce and the incidence of malformations, especially in experimental group 1are significantly high. The markedly limbs malformations are syndactyly, tetraductyly and phocomellya.Since the critical period of rat motor limbs embryonic development is between 11 to 13th post-mating day, the ESTRADIOL administration in group 1 probably by interrupting the programmed cell death phenomena or blocking the chemical receptors in limb bods produce limb abnormalities.

Cites

No record.

References

No record.

Cite

APA: Copy

NIKRAVESH, M.R., & BEHNAM RASOULI, MORTEZA. (2001). THE EVALUATION OF EVOLUTIONAL ESTRADIOL-INDIUCED DISORDERS ON MOTOR LIMBS OF RAT'S FETUSES. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 7(4 (SN 18)), 29-34. SID. https://sid.ir/paper/17792/en

Vancouver: Copy

NIKRAVESH M.R., BEHNAM RASOULI MORTEZA. THE EVALUATION OF EVOLUTIONAL ESTRADIOL-INDIUCED DISORDERS ON MOTOR LIMBS OF RAT'S FETUSES. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2001;7(4 (SN 18)):29-34. Available from: https://sid.ir/paper/17792/en

IEEE: Copy

M.R. NIKRAVESH, and MORTEZA BEHNAM RASOULI, “THE EVALUATION OF EVOLUTIONAL ESTRADIOL-INDIUCED DISORDERS ON MOTOR LIMBS OF RAT'S FETUSES,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 7, no. 4 (SN 18), pp. 29–34, 2001, [Online]. Available: https://sid.ir/paper/17792/en

Related Journal Papers