ASSOCIATION OF APO E AND APO B WITH ATHEROSCLEROSIS

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ASADPOUR PIRANFAR M.; PERADOL A.H.; ABDOLLAHI M.

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Journal: Researcher Bulletin of Medical Sciences Year:2006 | Volume:11 | Issue:4 (52) Page(s): 265-268

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Title

ASSOCIATION OF APO E AND APO B WITH ATHEROSCLEROSIS

Author(s)

ASADPOUR PIRANFAR M. | PERADOL A.H. | ABDOLLAHI M. | Issue Writer Certificate

Keywords

ATHEROSCLEROSISQ3

APOEQ3

APOBQ3

Abstract

Background: ATHEROSCLEROSIS is a common cardiovascular disease; many factors are effective on its occurrence. There are derangements in lipoprotein and lipid and enzyme level like as ApoA, APOB, ApoJ and APOE. APOE and APOB level assessment and relationship between these lipoproteins and ATHEROSCLEROSIS was investigated to help us, better diagnosis and predication of ATHEROSCLEROSIS related problems. Materials and Methods: A case - control study was performed in cardiology department (Taleghani hospital, Shaheed Beheshti -University), which included 25 ATHEROSCLEROSIS patients and 25 healthy people as control group ( at the range of 35-70 years old) and age, weight, smoking matched. We obtained 6 ml of venous blood from each one and after serum removal, APOE and APOB level was measured by ELISA method in endocrine and methabolism research center lab. Results: Mean APOB level in case group was 1.45 glL and 0.76 mg/L in control group. Mean APOE level in case group was 32.5 mg/Lit and 35.4 mg/L in control group. Difference in weight, age, blood pressure between case and control group was not important from statistical point of view The difference between case and control groups for APOB was 0.68 (P<0.01) and for APOE was 2.9 (P=0.46), the findings that measured are meaningful just for APOB trom statistical point of view.Conclusions: Although we consider difference between case and control groups in APOB and APOE level, and just difference in APOB level was considerable from statistical point of view. Former investigations also confirmed the relationship between APOB and ATHEROSCLEROSIS. But just some investigations show the relationship between ATHEROSCLEROSIS and APOE. These findings depend on different alleles. Therefore, that the increased level of APOE is a nonspecific factor for ATHEROSCLEROSIS process, and more investigations are necessary.

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APA: Copy

ASADPOUR PIRANFAR, M., PERADOL, A.H., & ABDOLLAHI, M.. (2006). ASSOCIATION OF APO E AND APO B WITH ATHEROSCLEROSIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 11(4 (52)), 265-268. SID. https://sid.ir/paper/18189/en

Vancouver: Copy

ASADPOUR PIRANFAR M., PERADOL A.H., ABDOLLAHI M.. ASSOCIATION OF APO E AND APO B WITH ATHEROSCLEROSIS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2006;11(4 (52)):265-268. Available from: https://sid.ir/paper/18189/en

IEEE: Copy

M. ASADPOUR PIRANFAR, A.H. PERADOL, and M. ABDOLLAHI, “ASSOCIATION OF APO E AND APO B WITH ATHEROSCLEROSIS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 11, no. 4 (52), pp. 265–268, 2006, [Online]. Available: https://sid.ir/paper/18189/en

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