EFFECT OF BILATERALLY LESION OF LATERAL HYPOTHALAMUS ON THE EFFECT OF D- GLUCOSE MICROINJECTION INTO THE VENTROMEDIAL HYPOTHALAMUS ON PENTAGASTRIN -STIMULATED GASTRIC ACID SECRETION IN MALE RAT

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NOUR ALDINI M.; ELIASI AFSANEH

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Journal: Researcher Bulletin of Medical Sciences Year:2005 | Volume:10 | Issue:3 (45) Page(s): 197-203

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Title

EFFECT OF BILATERALLY LESION OF LATERAL HYPOTHALAMUS ON THE EFFECT OF D- GLUCOSE MICROINJECTION INTO THE VENTROMEDIAL HYPOTHALAMUS ON PENTAGASTRIN -STIMULATED GASTRIC ACID SECRETION IN MALE RAT

Author(s)

NOUR ALDINI M. | ELIASI AFSANEH | Issue Writer Certificate

Keywords

LHQ3

VMHQ4

D-GLUCOSEQ4

GASTRIC ACID SECRETIONQ3

PENTAGASTRINQ4

Abstract

Background: Ventromedial (VMH) and Lateral (LH) hypothalamus are involved in central, but not peripheral. stimulation of GASTRIC ACID SECRETION (GAS). There are some evidences that glucose, an inhibitor of central- stimulated GAS, acts on glucosensitive neurons in VMH and LH. Evidences suggest that decreasing central stimulation of GAS is mediated by reciprocal connection between VMH and LH. The present study was designed to investigate the effect of lateral hypothalamic lesion on the effect of D-GLUCOSE microinjection into VMH on PENTAGASTRIN induced GAS.Materials and methods: The animals were anesthetized and placed in a stereotaxic instrument and guide cannulas were bilaterally implanted above (1 mm) VMH after bilateral electrolytic lesions of the lateral hypothalamus. Seven days after implantation, two polyethylene tubes were inserted into the stomach through esophagus and duoedonopyloric junction in anesthetised rat. After washing of the stomach with saline prewarmed to 370C for 15 min., the gastric secretory volume were collected at 5 minutes intervals. Fourty minutes after starting the intravenous injection of PENTAGASTRIN (2µg/100g/hr), D-GLUCOSE (30mM) was injected into the VMH.Results: Intravenous infusion of PENTAGASTRIN induced marked increase in GAS with a peak starting from 30 min up to the end of the experiments. In LH-lesioned rats, PENTAGASTRIN stimulated GAS was lower than that in sham-groups. Microinjection of D-GLUCOSE, but not L-glucose or saline, decreased gastric acid output in sham groups. No significant change in the acid output was noted after D-GLUCOSE injection into the VMH in LH-lesioned rats.Conclusion: Our findings show that 1) There are GAS-type glucosensitive neurons in VMH which affect the PENTAGASTRIN stimulated GAS. 2) GAS-type glucosensitive neurons arent sensitive to osmolarity, 3) The part of peripheral stimulation of GAS by PENTAGASTRIN is mediated by reciprocal connection between LH and VMH. 4) LH neurons appear to play a significant role in PENTAGASTRIN stimulated GAS.

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References

SURVEYING THE EFFECT OF INTRA GASTRIC ADMINISTRATION OF D-GLUCOSE ON HYPERACIDITY DUE TO PENTAGASTRIN IN RAT

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APA: Copy

NOUR ALDINI, M., & ELIASI, AFSANEH. (2005). EFFECT OF BILATERALLY LESION OF LATERAL HYPOTHALAMUS ON THE EFFECT OF D- GLUCOSE MICROINJECTION INTO THE VENTROMEDIAL HYPOTHALAMUS ON PENTAGASTRIN -STIMULATED GASTRIC ACID SECRETION IN MALE RAT. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 10(3 (45)), 197-203. SID. https://sid.ir/paper/18432/en

Vancouver: Copy

NOUR ALDINI M., ELIASI AFSANEH. EFFECT OF BILATERALLY LESION OF LATERAL HYPOTHALAMUS ON THE EFFECT OF D- GLUCOSE MICROINJECTION INTO THE VENTROMEDIAL HYPOTHALAMUS ON PENTAGASTRIN -STIMULATED GASTRIC ACID SECRETION IN MALE RAT. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2005;10(3 (45)):197-203. Available from: https://sid.ir/paper/18432/en

IEEE: Copy

M. NOUR ALDINI, and AFSANEH ELIASI, “EFFECT OF BILATERALLY LESION OF LATERAL HYPOTHALAMUS ON THE EFFECT OF D- GLUCOSE MICROINJECTION INTO THE VENTROMEDIAL HYPOTHALAMUS ON PENTAGASTRIN -STIMULATED GASTRIC ACID SECRETION IN MALE RAT,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 10, no. 3 (45), pp. 197–203, 2005, [Online]. Available: https://sid.ir/paper/18432/en

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