EVALUATION OF CA-125 IN MALIGNANCY OR TUBERCULOSIS - INDUCED EFFUSIONS

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SHOKOUHI SH.; SAMANABADI M.; GACHKAR L.

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Journal: Researcher Bulletin of Medical Sciences Year:2005 | Volume:10 | Issue:3 (45) Page(s): 161-165

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Title

EVALUATION OF CA-125 IN MALIGNANCY OR TUBERCULOSIS - INDUCED EFFUSIONS

Author(s)

SHOKOUHI SH. | SAMANABADI M. | GACHKAR L. | Issue Writer Certificate

Keywords

MALIGNANCYQ3

PLEURAL EFFUSIONQ2

TUMOR MARKERQ3

CA-125Q4

TUBERCULOSISQ4

Abstract

Background: Primary and secondary infections and malignancies are inflammatory causes of fluid accumulation in pleural space. TUBERCULOSIS (TB) induces PLEURAL EFFUSION similar to malignancies because of its sub acute and chronic process, although the management of two diseases is extremely different. CA-125, a glycoprotein TUMOR MARKER with molecular weight of 200 kilo Dalton, is found on the surface of ovarian and some normal and inflammatory cells in TUBERCULOSIS. This marker increases in serum, as well as in pleural fluid in the presence of MALIGNANCY or TB. This study was performed to evaluate and compare CA-125 marker in PLEURAL EFFUSION induced by malignancies and TUBERCULOSIS.Materials and methods: In this descriptive - diagnostic study, we evaluated patients with PLEURAL EFFUSION in Shaheed Beheshti University hospitals from 2004 to 2005. Patients with benign causes of PLEURAL EFFUSION were excluded, and patients with diagnosis of malignancies (regarding histology, biopsy and pleural fluid cytology) or TUBERCULOSIS (using sputum culture and smear, BAL, pleural fluid PCR, or pleural biopsy), entered the study. CA-125 was evaluated in pleural fluid using chemiluminesca immune assay. Comparing the results was performed using Mann Whitney method. P<0.05 was considered as significant.Results: Twenty-seven patients with TUBERCULOSIS and 23 patients with MALIGNANCY were evaluated. Mean CA-125 level was 159.1214, and 2149.24513.6 U/ml in TUBERCULOSIS and malignancies, respectively; with statistically significant difference between these groups (P<0.01). Also, using ROC curve, appropriate cut off point to determine TUBERCULOSIS PLEURAL EFFUSION from MALIGNANCY PLEURAL EFFUSION was measured to be 221.5-253.5 U/ml.Amounts below this figure is favor of TB PLEURAL EFFUSION, while amounts over it is in favor of a MALIGNANCY induced PLEURAL EFFUSION.Conclusion: It seems that serom concentration of CA-125 can be used as a diagnostic index for differentiation of TB and MALIGNANCY induced PLEURAL EFFUSIONs.

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APA: Copy

SHOKOUHI, SH., SAMANABADI, M., & GACHKAR, L.. (2005). EVALUATION OF CA-125 IN MALIGNANCY OR TUBERCULOSIS - INDUCED EFFUSIONS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 10(3 (45)), 161-165. SID. https://sid.ir/paper/18435/en

Vancouver: Copy

SHOKOUHI SH., SAMANABADI M., GACHKAR L.. EVALUATION OF CA-125 IN MALIGNANCY OR TUBERCULOSIS - INDUCED EFFUSIONS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2005;10(3 (45)):161-165. Available from: https://sid.ir/paper/18435/en

IEEE: Copy

SH. SHOKOUHI, M. SAMANABADI, and L. GACHKAR, “EVALUATION OF CA-125 IN MALIGNANCY OR TUBERCULOSIS - INDUCED EFFUSIONS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 10, no. 3 (45), pp. 161–165, 2005, [Online]. Available: https://sid.ir/paper/18435/en

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