ASSOCIATION BETWEEN THE VEGF (2578C/A) AND KDR (Q724H) GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION VEGF AND KDR GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION

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BAHRAMI HIDAJI FERESHTEH; ASAADI TEHRANI GOLNAZ

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Journal: Researcher Bulletin of Medical Sciences Year:2016 | Volume:21 | Issue:1 (109) Page(s): 6-12

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Title

ASSOCIATION BETWEEN THE VEGF (2578C/A) AND KDR (Q724H) GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION VEGF AND KDR GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION

Author(s)

BAHRAMI HIDAJI FERESHTEH | ASAADI TEHRANI GOLNAZ | Issue Writer Certificate

Keywords

RECURRENT PREGNANCY LOSS (RPL)Q1

VEGF GENEQ1

KDR RECEPTORQ1

Abstract

Background and Aim: Vascular Endothelial Growth Factor (VEGF) and its kinase insert domain receptor (KDR) are crucial for angiogenesis and embryonic development. However, limited information is available regarding the role of the VEGF system, especially its KDR RECEPTOR, in recurrent pregnancy loss (RPL). This study aimed to investigate genetic association between VEGF and its receptor gene (KDR) polymorphisms with idiopathic RPL.Materials and Methods: In this case-control study, 50 women who had experienced at least two consecutive spontaneous miscarriages and 50 controls with at least two live births without a miscarriage were included. 2578C/A polymorphism for VEGF GENE and Q724H polymorphism for KDR gene, were genotyped using Tetra-Primer ARMS-PCR and PCR–RFLP methods respectively. Achieved results were analyzed statically by the SPSS-16 and chi square methods.Results: The frequency of AC, CC and AA genotypes of VEGF polymorphism in the control and case groups was computed 56, 20, 24% and 26, 46, 28%, respectively (p<0.003). Furthermore, for KDR polymorphism AA, AT and TT genotypes for control 42, 42, 16% and in the case group were detected 30, 68 and 2% (p<0.009).Conclusion: It seems that 2578C/A and Q472H polymorphisms in genes VEGF and its receptor gene (KDR) are associated with idiopathic RPL in Iranian women.

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References

FETAL VEGF GENOTYPE IS MORE IMPORTANT FOR ABORTION RISK THAN MOTHER GENOTYPE

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APA: Copy

BAHRAMI HIDAJI, FERESHTEH, & ASAADI TEHRANI, GOLNAZ. (2016). ASSOCIATION BETWEEN THE VEGF (2578C/A) AND KDR (Q724H) GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION VEGF AND KDR GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 21(1 (109)), 6-12. SID. https://sid.ir/paper/18561/en

Vancouver: Copy

BAHRAMI HIDAJI FERESHTEH, ASAADI TEHRANI GOLNAZ. ASSOCIATION BETWEEN THE VEGF (2578C/A) AND KDR (Q724H) GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION VEGF AND KDR GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2016;21(1 (109)):6-12. Available from: https://sid.ir/paper/18561/en

IEEE: Copy

FERESHTEH BAHRAMI HIDAJI, and GOLNAZ ASAADI TEHRANI, “ASSOCIATION BETWEEN THE VEGF (2578C/A) AND KDR (Q724H) GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION VEGF AND KDR GENE POLYMORPHISMS AND RECURRENT SPONTANEOUS ABORTION,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 21, no. 1 (109), pp. 6–12, 2016, [Online]. Available: https://sid.ir/paper/18561/en

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