NANOGOLD FOR THE TREATMENT OF ZOONOTIC CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR (MRHO/IR/75/ER): AN ANIMAL TRIAL WITH METHANOL EXTRACT OF EUCALYPTUS CAMALDULENSIS

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TORABI NEGIN; MOHEBALI MEHDI; SHAHVERDI AHMAD REZA; REZAYAT SEYED MEHDI; EDRISSIAN GHOLAM HOSSEIN; ESMAEILI JAMILEH; CHAREHDAR SOROUR

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Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2011 | Volume:1 | Issue:1 Page(s): 13-16

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Title

NANOGOLD FOR THE TREATMENT OF ZOONOTIC CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR (MRHO/IR/75/ER): AN ANIMAL TRIAL WITH METHANOL EXTRACT OF EUCALYPTUS CAMALDULENSIS

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Keywords

LEISHMANIA MAJORQ1

CUTANEOUS LEISHMANIASISQ1

NANOGOLDQ1

BALB/C MICEQ1

Abstract

This experimental study was conducted to assess of effectiveness of two NANOGOLD concentrations against CUTANEOUS LEISHMANIASIS (CL) caused by Iranian strain of LEISHMANIA MAJOR in BALB/C MICE model. Cutaneous lesions were experimentally induced by inoculation with Iranian LEISHMANIA MAJOR promastigotes (MRHO/IR/75/ER) in 61 BALB/C MICE. The infected mice were enrolled to four groups: interventional groups which were treated with two different concentrations of NANOGOLD and two control groups. NANOGOLD solutions applied topically twice daily for 28 days (N=30) and the results compared with control groups (N=31).The results showed that amastigote number into the lesions, were significantly decreased in interventional groups compared with control groups (p=0.001). NANOGOLD solutions were also decreased mortality rate in the mice (p=0.003). No statistically difference was found between 40 mg/ml and 0.4mg/ml of NANOGOLD concentrations in amastigote reduction (p=0.648).

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APA: Copy

TORABI, NEGIN, MOHEBALI, MEHDI, SHAHVERDI, AHMAD REZA, REZAYAT, SEYED MEHDI, EDRISSIAN, GHOLAM HOSSEIN, ESMAEILI, JAMILEH, & CHAREHDAR, SOROUR. (2011). NANOGOLD FOR THE TREATMENT OF ZOONOTIC CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR (MRHO/IR/75/ER): AN ANIMAL TRIAL WITH METHANOL EXTRACT OF EUCALYPTUS CAMALDULENSIS. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 1(1), 13-16. SID. https://sid.ir/paper/188767/en

Vancouver: Copy

TORABI NEGIN, MOHEBALI MEHDI, SHAHVERDI AHMAD REZA, REZAYAT SEYED MEHDI, EDRISSIAN GHOLAM HOSSEIN, ESMAEILI JAMILEH, CHAREHDAR SOROUR. NANOGOLD FOR THE TREATMENT OF ZOONOTIC CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR (MRHO/IR/75/ER): AN ANIMAL TRIAL WITH METHANOL EXTRACT OF EUCALYPTUS CAMALDULENSIS. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2011;1(1):13-16. Available from: https://sid.ir/paper/188767/en

IEEE: Copy

NEGIN TORABI, MEHDI MOHEBALI, AHMAD REZA SHAHVERDI, SEYED MEHDI REZAYAT, GHOLAM HOSSEIN EDRISSIAN, JAMILEH ESMAEILI, and SOROUR CHAREHDAR, “NANOGOLD FOR THE TREATMENT OF ZOONOTIC CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA MAJOR (MRHO/IR/75/ER): AN ANIMAL TRIAL WITH METHANOL EXTRACT OF EUCALYPTUS CAMALDULENSIS,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 1, no. 1, pp. 13–16, 2011, [Online]. Available: https://sid.ir/paper/188767/en

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