Evaluation of Bcl-2 and Bax Expression in the Heart of Diabetic Rats after Four Weeks of High Intensity Interval Training

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Ramezani Nasrin; VANAKY BEHNAZ; Shakeri Nader; Soltanian Zahra; Fakhari Rad Fatemeh; SHAMS ZAHRA

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Journal: MEDICAL LABORATORY JOURNAL Year:2019 | Volume:13 | Issue:1 Page(s): 15-20

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Title

Evaluation of Bcl-2 and Bax Expression in the Heart of Diabetic Rats after Four Weeks of High Intensity Interval Training

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Keywords

BaxQ4

Bcl-2Q4

High intensity interval trainingQ4

HeartQ4

Type 2 diabetesQ4

Abstract

Background and Objectives: Diabetes is one of the most common diseases and a major risk factor for cardiovascular disease. Studies have shown that regular exercise can affect apoptosis in cardiomyocytes. The purpose of this study was to investigate the effect of high-intensity interval training on the expression of Bcl-2 and Bax as important apoptosis factors in diabetic rats. Methods: After inducing diabetes in 20 male Wistar rats (weighing 250 ± 1. 15 g), the rats were randomly divided into a control group and a training group. The training group performed high-intensity interval training five days a week for four weeks, and the control group did not perform any training. After the intervention, RNA was extracted and TCF mRNA was subjected to real time RT-PCR for measuring Bax and Bcl-2 expression in the Heart tissue of diabetic rats. Data were analyzed by IBM SPSS Statistics V22 using independent t-test. P-values less than 0. 05 were considered as statistically significant. Results: The expression of Bcl-2 increased significantly and the expression of Bax decreased significantly after the four-week training intervention. Conclusion: The high-intensity interval training can have beneficial effects on the expression of apoptotic genes in rats with Type 2 diabetes.

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APA: Copy

Ramezani, Nasrin, VANAKY, BEHNAZ, Shakeri, Nader, Soltanian, Zahra, Fakhari Rad, Fatemeh, & SHAMS, ZAHRA. (2019). Evaluation of Bcl-2 and Bax Expression in the Heart of Diabetic Rats after Four Weeks of High Intensity Interval Training. MEDICAL LABORATORY JOURNAL, 13(1), 15-20. SID. https://sid.ir/paper/194807/en

Vancouver: Copy

Ramezani Nasrin, VANAKY BEHNAZ, Shakeri Nader, Soltanian Zahra, Fakhari Rad Fatemeh, SHAMS ZAHRA. Evaluation of Bcl-2 and Bax Expression in the Heart of Diabetic Rats after Four Weeks of High Intensity Interval Training. MEDICAL LABORATORY JOURNAL[Internet]. 2019;13(1):15-20. Available from: https://sid.ir/paper/194807/en

IEEE: Copy

Nasrin Ramezani, BEHNAZ VANAKY, Nader Shakeri, Zahra Soltanian, Fatemeh Fakhari Rad, and ZAHRA SHAMS, “Evaluation of Bcl-2 and Bax Expression in the Heart of Diabetic Rats after Four Weeks of High Intensity Interval Training,” MEDICAL LABORATORY JOURNAL, vol. 13, no. 1, pp. 15–20, 2019, [Online]. Available: https://sid.ir/paper/194807/en

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