EFFECT OF AQUATIC EXTRACT OF ACHILLEA MILLEFOLIUM ON SPERM AND IN VITRO FERTILIZATION IN ADULT RATS TREATED WITH CYCLOSPORINE A

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AKBARIZADEH Z.; NAJAFI GH.; FAROKHI F.

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Title

EFFECT OF AQUATIC EXTRACT OF ACHILLEA MILLEFOLIUM ON SPERM AND IN VITRO FERTILIZATION IN ADULT RATS TREATED WITH CYCLOSPORINE A

Author(s)

AKBARIZADEH Z. | NAJAFI GH. | FAROKHI F. | Issue Writer Certificate

Keywords

SPERMQ2

ACHILLEA MILLEFOLIUMQ2

CYCLOSPORINEQ3

RATQ2

IVFQ2

Abstract

Introduction: In this study we aimed to evaluate the protective effect of aqueous extract of ACHILLEA MILLEFOLIUM on SPERM parameters in vitro fertilization against cyclosporin A-induced embryo toxicity. Cyclosporin A is an immunosuppressant drug widely used in organ transplantation to prevent rejection. cyclosporin A reduces the activity of the immune system by interfering with the activity and growth of T cells. ACHILLEA MILLEFOLIUM, a widely distributed medicinal plant, is highly regarded for its medicinal activities, including antioxidant and anti-inflammatory properties.methods: In this study, 44 adult Wistar RATs were divided into 4 groups as control, CYCLOSPORINE (30 mg/kg), ACHILLEA MILLEFOLIUM (150 mg/kg) and CYCLOSPORINE-Achillea millefolium group (30mg - 150 mg/kg). At 21 and 45 days SPERM characteristics and fertility Evaluated.Result: The CYCLOSPORINE treated group showed significant (P<0.05) decrease in the SPERM count, SPERM viability and in vitro fertilization. ACHILLEA MILLEFOLIUM co-administration caused an increase in above-mentioned parameters.Conclusion: These findings manifested that ACHILLEA MILLEFOLIUM aqueous extract may be partially protective against CYCLOSPORINE -induced embryo toxicity.

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APA: Copy

AKBARIZADEH, Z., NAJAFI, GH., & FAROKHI, F.. (2013). EFFECT OF AQUATIC EXTRACT OF ACHILLEA MILLEFOLIUM ON SPERM AND IN VITRO FERTILIZATION IN ADULT RATS TREATED WITH CYCLOSPORINE A. JOURNAL OF ZABOL UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES (JOURNAL OF ROSTAMINEH), 4(4), 9-18. SID. https://sid.ir/paper/203590/en

Vancouver: Copy

AKBARIZADEH Z., NAJAFI GH., FAROKHI F.. EFFECT OF AQUATIC EXTRACT OF ACHILLEA MILLEFOLIUM ON SPERM AND IN VITRO FERTILIZATION IN ADULT RATS TREATED WITH CYCLOSPORINE A. JOURNAL OF ZABOL UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES (JOURNAL OF ROSTAMINEH)[Internet]. 2013;4(4):9-18. Available from: https://sid.ir/paper/203590/en

IEEE: Copy

Z. AKBARIZADEH, GH. NAJAFI, and F. FAROKHI, “EFFECT OF AQUATIC EXTRACT OF ACHILLEA MILLEFOLIUM ON SPERM AND IN VITRO FERTILIZATION IN ADULT RATS TREATED WITH CYCLOSPORINE A,” JOURNAL OF ZABOL UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES (JOURNAL OF ROSTAMINEH), vol. 4, no. 4, pp. 9–18, 2013, [Online]. Available: https://sid.ir/paper/203590/en

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