EVALUATION OF THE ANTIBACTERIAL EFFECTS OF THE NEW BENZOTHIAZOLE AND TETRAHYDROPYRIMIDINE DERIVATIVES AGAINST STREPTOCOCCUS INIAE, EDWARDSIELLA TARDA AND AEROMONAS HYDROPHILA AS SOME ZOONOTIC BACTERIAL PATHOGENS

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ARYAN R.; GHASEMI B.; BEYZAEI H.; NAJIMI M.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2016 | Volume:6 | Issue:2 Page(s): 162-168

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Title

EVALUATION OF THE ANTIBACTERIAL EFFECTS OF THE NEW BENZOTHIAZOLE AND TETRAHYDROPYRIMIDINE DERIVATIVES AGAINST STREPTOCOCCUS INIAE, EDWARDSIELLA TARDA AND AEROMONAS HYDROPHILA AS SOME ZOONOTIC BACTERIAL PATHOGENS

Author(s)

ARYAN R. | GHASEMI B. | BEYZAEI H. | NAJIMI M. | Issue Writer Certificate

Keywords

ANTIBACTERIALQ2

ZOONOTIC BACTERIAQ1

BENZOTHIAZOLE AND TETRAHYDROPYRIMIDINEQ1

Abstract

Background & Objective: The novel stronger ANTIBACTERIAL compounds such as the thiazole and pyrimidine derivatives are needed in order to remove the threat of bacterial antibiotic resistance in zoonotic aquatic bacterial pathogens. In this study, we evaluated the inhibitory effect of the new BENZOTHIAZOLE AND TETRAHYDROPYRIMIDINE derivatives against three important zoonotic aquatic pathogens including Streptococcus iniae, Edwardsiella tarda and Aeromonas hydrophila.Material & Methods: BENZOTHIAZOLE AND TETRAHYDROPYRIMIDINE derivatives were synthesized and dissolved in DMSO with a concentration of 8129 mg/mL. Then, the disk diffusion and broth microdilution methods were applied to evaluate the ANTIBACTERIAL effects. Results were recorded as the minimum inhibitory concentration (MIC) and the growth inhibition zone diameter.Results: The study showed that the two tetrahydropyrimidine derivatives had no inhibition effects on all of the studied bacteria. Moreover, no inhibitory effect was observed from the three banzothiazole derivatives against A. hydrophila. However, the benzothiazole derivatives showed significant inhibitory effect against S. iniae and E. tarda with MIC of 256-1024 mg/mL and the growth inhibition zone diameter of 4.3±0.3-18.2±0.1 mm.Conclusion: The ANTIBACTERIAL effect of the new banzothiazole derivatives was confirmed on S. iniae and E. tarda pathogens for the first time.

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APA: Copy

ARYAN, R., GHASEMI, B., BEYZAEI, H., & NAJIMI, M.. (2016). EVALUATION OF THE ANTIBACTERIAL EFFECTS OF THE NEW BENZOTHIAZOLE AND TETRAHYDROPYRIMIDINE DERIVATIVES AGAINST STREPTOCOCCUS INIAE, EDWARDSIELLA TARDA AND AEROMONAS HYDROPHILA AS SOME ZOONOTIC BACTERIAL PATHOGENS. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 6(2), 162-168. SID. https://sid.ir/paper/203883/en

Vancouver: Copy

ARYAN R., GHASEMI B., BEYZAEI H., NAJIMI M.. EVALUATION OF THE ANTIBACTERIAL EFFECTS OF THE NEW BENZOTHIAZOLE AND TETRAHYDROPYRIMIDINE DERIVATIVES AGAINST STREPTOCOCCUS INIAE, EDWARDSIELLA TARDA AND AEROMONAS HYDROPHILA AS SOME ZOONOTIC BACTERIAL PATHOGENS. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2016;6(2):162-168. Available from: https://sid.ir/paper/203883/en

IEEE: Copy

R. ARYAN, B. GHASEMI, H. BEYZAEI, and M. NAJIMI, “EVALUATION OF THE ANTIBACTERIAL EFFECTS OF THE NEW BENZOTHIAZOLE AND TETRAHYDROPYRIMIDINE DERIVATIVES AGAINST STREPTOCOCCUS INIAE, EDWARDSIELLA TARDA AND AEROMONAS HYDROPHILA AS SOME ZOONOTIC BACTERIAL PATHOGENS,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 6, no. 2, pp. 162–168, 2016, [Online]. Available: https://sid.ir/paper/203883/en

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