The Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats

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JAFARZADEH GH.; SHAKERIAN SAEED; FARBOOD Y.; GHANBARZADEH M.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2019 | Volume:8 | Issue:4 Page(s): 1167-1176

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Title

The Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats

Author(s)

JAFARZADEH GH. | SHAKERIAN SAEED | FARBOOD Y. | GHANBARZADEH M. | Issue Writer Certificate

Keywords

AlzheimerQ2

BDNFQ2

Gene ExpressionQ1

TrkB ReceptorQ1

Resistance ExercisesQ1

RatQ2

Abstract

Background & Objective: This study was intended to evaluate the effect of One Session of Resistance Exercises on expression of BDNF gene and TrkB Receptor in Alzheimer model male Wistar Rats. Materials & Methods: 32 mature male Wistar Rats with mean weight of 230 to 280 grams were chosen and divided into Alzheimer and Sham groups. Rats in Sham group received normal saline while Rats in Alzheimer group received STZ via intraventricular injection. These Rats were then divided into the following four subgroups: 1. Resting Sham, 2. Exercising Sham, 3. Resting Alzheimer, and 4. Exercising Alzheimer. The two exercising Rat subgroups, exercised 3 times a week for a period of 8 weeks. Exercise included lifting weight from the ladder. At the end of 8th week and 24 hours after last exercise session, the Rats were scarified by head sepaRation. Hippocampus tissue was precisely extracted and samples were sent to laboRatory for molecular and cellular tests. To determine the Gene Expression, RT-PCR method was used for analyzing the data and ANOVA was used. Results: The amount of BDNF, and TrkB between exercising Rats and resting Rats were measured. These amounts were much higher in exercising Alzheimer Rats group. Conclusion: It seems that eight weeks of Resistance Exercises increased expression of BDNF gene and TrkA an TrkB Receptor in Alzheimer model Wistar Rats.

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APA: Copy

JAFARZADEH, GH., SHAKERIAN, SAEED, FARBOOD, Y., & GHANBARZADEH, M.. (2019). The Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(4 ), 1167-1176. SID. https://sid.ir/paper/203972/en

Vancouver: Copy

JAFARZADEH GH., SHAKERIAN SAEED, FARBOOD Y., GHANBARZADEH M.. The Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2019;8(4 ):1167-1176. Available from: https://sid.ir/paper/203972/en

IEEE: Copy

GH. JAFARZADEH, SAEED SHAKERIAN, Y. FARBOOD, and M. GHANBARZADEH, “The Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 4 , pp. 1167–1176, 2019, [Online]. Available: https://sid.ir/paper/203972/en

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