Interaction Effect of High Interval and Low Intensity Continuous Trainings with Crocin on the Expressions of PGC-1a and UCP1 in Heart Tissue of Male Diabetic Rats

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Alaie Maryam; GAEINI ABBAS ALI; NOURI REZA; CHOOBINEH SIROOS

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Journal: Research in Medicine Year:2020 | Volume:44 | Issue:3 Page(s): 423-429

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Title

Interaction Effect of High Interval and Low Intensity Continuous Trainings with Crocin on the Expressions of PGC-1a and UCP1 in Heart Tissue of Male Diabetic Rats

Author(s)

Alaie Maryam | GAEINI ABBAS ALI | NOURI REZA | CHOOBINEH SIROOS | Issue Writer Certificate

Keywords

TrainingQ1

CrocinQ1

DiabetesQ2

Heart TissueQ1

Mitochondrial BiogenesisQ1

Abstract

Background: Diabetes is a form of metabolic disease whose sufferers are constantly exposed to cardiovascular diseases. Exercise Training and diet are two important factors in managing this disease. Thus, the aim of the present study was to investigate the interactive effect of high intensity interval and low intensity continuous Trainings and Crocin on the expressions of PGC1-α and UCP1 genes in Heart Tissue of diabetic rats. Materials and Methods: In the present experimental study, 56 diabetic male rats (induced by highfat diet and injections Stz) were divided into seven groups: 1) High Intensity Interval Training, 2) High Intensity Interval Training and Crocin consumption, 3) Low Intensity Continuous Trainings, 4) Low Intensity Continuous Trainings and Crocin consumption, 5) Sham, 6) Crocin consumption, and 7) Control. Both High Intensity Interval and Low Intensity Continuous Training groups were trained on the treadmill 3 sessions per week for 8 weeks, respectively, with the intensities of 80 to 85 and 50 to 55 percent of maximum running speed on rodent treadmill; Crocin consumption group received 25 mg/kg Crocin per day for 8 weeks. The data were analyzed running Paired sample t-test, two-way ANOVA, and Bonferron's post hoc tests (p≤ 0. 05). Results: Training (p = 0. 001) and Crocin consumption (p = 0. 001) significantly increased the expressions of PGC1-α and UCP1. Also, Training with Crocin consumption was found to have interactive effects on increasing the expressions of PGC1-α (p = 0. 001) and UCP1 (p = 0. 001) and high intensity interval and low intensity continuous Trainings have the same effects on the increase of UCP1 expression (p = 0. 02). Conclusion: It seems that high intensity interval and low intensity continuous Training with Crocin consumption had interactive effects on the improvement of PGC1-α and UCP1 gene expression levels in Heart Tissue of diabetic rats.

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APA: Copy

Alaie, Maryam, GAEINI, ABBAS ALI, NOURI, REZA, & CHOOBINEH, SIROOS. (2020). Interaction Effect of High Interval and Low Intensity Continuous Trainings with Crocin on the Expressions of PGC-1a and UCP1 in Heart Tissue of Male Diabetic Rats. PAJOUHESH DAR PEZESHKI, 44(3 ), 423-429. SID. https://sid.ir/paper/384656/en

Vancouver: Copy

Alaie Maryam, GAEINI ABBAS ALI, NOURI REZA, CHOOBINEH SIROOS. Interaction Effect of High Interval and Low Intensity Continuous Trainings with Crocin on the Expressions of PGC-1a and UCP1 in Heart Tissue of Male Diabetic Rats. PAJOUHESH DAR PEZESHKI[Internet]. 2020;44(3 ):423-429. Available from: https://sid.ir/paper/384656/en

IEEE: Copy

Maryam Alaie, ABBAS ALI GAEINI, REZA NOURI, and SIROOS CHOOBINEH, “Interaction Effect of High Interval and Low Intensity Continuous Trainings with Crocin on the Expressions of PGC-1a and UCP1 in Heart Tissue of Male Diabetic Rats,” PAJOUHESH DAR PEZESHKI, vol. 44, no. 3 , pp. 423–429, 2020, [Online]. Available: https://sid.ir/paper/384656/en

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