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Information Journal Paper

Title

EVALUATION OF THE EFFECT OF MALVA PARVIFLORA HYDRO-ALCOHOLIC EXTRACT ON PAIN IN MALE RAT

Pages

  95-105

Abstract

 Background and Objective: Due to the low side effects of active ingredients of medicinal plants, they are considered appropriate alternatives to synthetic drugs.Malva periflora has antiinflammation effects in folk and herbal medicine. In this study the anti-nociceptive and anti-inflammatory effects of Malva parviflora were investigated.Subjects and Methods: In this study seventy two Wister male RATs were used: negative control group that received no treatment, sham group received normal saline (1ml), Test groups received respectively 100, 200, 400, 600 or 800 mg/Kg extract for 10 days by gavages. Positive control group received 600 mg/Kg extract with 300 mg/Kg ASPIRIN intraperitoneally; Group received 600 mg/Kg extract and naloxone (10 mg/Kg) intraperitoneally. PAIN was tested by FORMALIN TEST by subcutaneous administration of 50 ml formalin 2.5% in hindpow plantar.Results: Malva extract had a dose-dependent anti-nociceptive effect on both acute and chronic PAINs induced by the formalin injection (P<0.05). In the acute phase Malva lost its analogesic effect due to the inhibitation of opioid receptor by naloxone. But in the inflammatory phase, this effect was weaker in comparison with ASPIRIN. On the other hand, effective dose (600 mg/Kg) of extract with naloxone decreased significantly as compared to effective dose of extract alone.Conclusion: MALVA PARVIFLORA EXTRACT has flavonoid and antiinflammatory compounds. Yet prostaglandins release could probably be decreased by inhibiting cyclooxygenase activity.So it reduces PAIN in chronic phase thanks to its anti-inflammatory properties.

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References

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APA: Copy

PARTO, NARGES, VALIZADEH, ZOHREH, SARKAKI, ALIREZA, & NASRI, SIMA. (2018). EVALUATION OF THE EFFECT OF MALVA PARVIFLORA HYDRO-ALCOHOLIC EXTRACT ON PAIN IN MALE RAT. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 17(1 ), 95-105. SID. https://sid.ir/paper/12329/en

Vancouver: Copy

PARTO NARGES, VALIZADEH ZOHREH, SARKAKI ALIREZA, NASRI SIMA. EVALUATION OF THE EFFECT OF MALVA PARVIFLORA HYDRO-ALCOHOLIC EXTRACT ON PAIN IN MALE RAT. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2018;17(1 ):95-105. Available from: https://sid.ir/paper/12329/en

IEEE: Copy

NARGES PARTO, ZOHREH VALIZADEH, ALIREZA SARKAKI, and SIMA NASRI, “EVALUATION OF THE EFFECT OF MALVA PARVIFLORA HYDRO-ALCOHOLIC EXTRACT ON PAIN IN MALE RAT,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 17, no. 1 , pp. 95–105, 2018, [Online]. Available: https://sid.ir/paper/12329/en

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