INVESTIGATING THE INFLUENCE OF FREQUENT CYANIDE-ISOPROTERENOL PRESCRIPTION ON THE FUNCTION OF ISOLATED RAT HEART IN ISCHEMIC AND NORMAL STATUS

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SHAKIBAEI D.; MORADI B.; ALMASSI M.

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Journal: Journal of Kermanshah University of Medical Sciences Year:2000 | Volume:4 | Issue:1 Page(s): 28-38

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Title

INVESTIGATING THE INFLUENCE OF FREQUENT CYANIDE-ISOPROTERENOL PRESCRIPTION ON THE FUNCTION OF ISOLATED RAT HEART IN ISCHEMIC AND NORMAL STATUS

Author(s)

SHAKIBAEI D. | MORADI B. | ALMASSI M. | Issue Writer Certificate

Keywords

ISCHEMIAQ2

CYANIDEQ3

ISOPROTERENOLQ2

HEART HYPERTROPHYQ3

CYTOCHROME OXIDASE ENZYMEQ4

Abstract

Today one of the most common causes of mortality in the world is cardiac ischemic diseases. Regarding the oxygen demand increase in the hypertrophy heart, its vulnerability to ISCHEMIA raises and this research was aimed to find the answer to the question whether it is possible to reduce the vulnerability by an intervention in the process of cardiac hypertrophia. The present study was carried out on three groups of rats (n=37) selected randomly: The first group received 0.4 mg/kg/day ISOPROTERENOL (ISO) for seven successive days. Similarly, the second group received 0.12 mg/kg/day ISO with CYANIDE and the last group, as a control group, was prescribed with the same volume of normal saline. Then the rat hearts were isolated and perfused in normal periods (20 min), ischemic periods (by perfusion reduction to the initial state for 30 min) and turn to normal state (30 min). The results indicated that LVP and dp/dt in the first group (95.73±11.44 mmHg, 3575± 5.9mmHg/sec.) and the second one (89.9±11.04mmHg, 2102± 22mmHg/sec.) were more of the control group (58.06± 7.16mmHg, 1500±222mmHg/sec.) and the differences among experimental groups and control group were statistically significant (P<0.005, P<0.025). Meanwhile the percent rates of alterations of LVP and dp/dt after the ischemic period in the first group (-21.64± 6.94, -42.03 ± 6) were significantly decreased in comparison to control group (26.83 ±14.42, 22.23 ± 17.47), while these alterations were not seen in the second group (0.137 ±15.08, 12.85 ±21.91).These results, on the one hand, suggested the incidence of hypertrophy in both experimental groups relative to control group. On the other hand, the heart received ISO with CYANIDE were less vulnerable to ISCHEMIA than those received merely ISO. This probably is due to the effect of CYANIDE on cytochrome oxidase and the activation of the aforementioned protective mechanism which needs more complementary studies to clear up its mechanisms.

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APA: Copy

SHAKIBAEI, D., MORADI, B., & ALMASSI, M.. (2000). INVESTIGATING THE INFLUENCE OF FREQUENT CYANIDE-ISOPROTERENOL PRESCRIPTION ON THE FUNCTION OF ISOLATED RAT HEART IN ISCHEMIC AND NORMAL STATUS. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 4(1), 28-38. SID. https://sid.ir/paper/20756/en

Vancouver: Copy

SHAKIBAEI D., MORADI B., ALMASSI M.. INVESTIGATING THE INFLUENCE OF FREQUENT CYANIDE-ISOPROTERENOL PRESCRIPTION ON THE FUNCTION OF ISOLATED RAT HEART IN ISCHEMIC AND NORMAL STATUS. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2000;4(1):28-38. Available from: https://sid.ir/paper/20756/en

IEEE: Copy

D. SHAKIBAEI, B. MORADI, and M. ALMASSI, “INVESTIGATING THE INFLUENCE OF FREQUENT CYANIDE-ISOPROTERENOL PRESCRIPTION ON THE FUNCTION OF ISOLATED RAT HEART IN ISCHEMIC AND NORMAL STATUS,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 4, no. 1, pp. 28–38, 2000, [Online]. Available: https://sid.ir/paper/20756/en

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